Products

Human IFN-gamma ELISpot Kit

DESCRIPTION
CATALOG #
SIZEPRICEQTY 
Human IFN-gamma ELISpot Kit
EL285 1 Kit $445
Human IFN-gamma ELIPACK (50 Plates)
PEL285 1 Pack Please Inquire
Human IFN-gamma ELISpot SixPak (6 Plates)
XEL285 1 Pack $1,870

Molecule Information: IFN-gamma
Long Name: Interferon gamma
 
Aliases: IFNG
Entrez Gene IDs: 3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)
Background: IFN-gamma

Interferon-γ (IFN-γ, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. Human IFN-γ is highly species specific and is biologically active only in human and primate cells.

IFN-γ was originally characterized based on its antiviral activities. The protein also exerts anti-proliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, up-regulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments Helper T cell expansion and may be required for Helper T cell differentiation.

IFN-γ exerts its biological activities by binding to specific cell surface receptors with high-affinity binding sites. The IFN-γ receptor is present on almost all cell types except mature erythrocytes and has been cloned and characterized. The IFN-γ receptor is structurally related to the IL-10 receptor.

SUPPLEMENTAL PRODUCTS
Supplemental ELISA Products
DESCRIPTION CATALOG # SIZE PRICE QUANTITY  
ELISA Plate Sealers, 100 Pack DY992 1 Pack $65
R&D SYSTEMS ARTICLES RELATED TO IFN-gamma
R&D SYSTEMS ARTICLES HIGHLIGHTING Single Analyte ELISpot Kits