4-1BB Ligand
4-1BB Ligand (4-1BBL/TNFSF9) is a type II transmembrane glycoprotein predominantly expressed on B cells, macrophages, dendritic cells (DCs), and on most T and B lymphoma cell lines. 4-1BBL binds the receptor 4-1BB and transduces a co-stimulatory signal in both CD4+ and CD8+ T cells to promote survival, proliferation, cytokine production, and effector function. In addition, 4-1BB is a DC-activating molecule that enhances cytokine production and expression of B7-1 and B7-2.
Recombinant Mouse 4-1BB Ligand/TNFSF9
4-1BB
4-1BB (CD137/ILA/TNFRSF9) is expressed on activated CD4+ and CD8+ T cells, thymocytes, NK cells, monocytes, neutrophils, DCs, and eosinophils. In response to its ligand 4-1BBL, 4-1BB transduces a co-stimulatory signal in both CD4+ and CD8+ T cells to promote survival, proliferation, cytokine production, and effector function, and in vivo is important in graft-vs-host diseases and anti-viral CTL responses.
Recombinant Mouse 4-1BB (TNFRSF9)/Fc Chimera
- Catalog Number: 937-4B-050
- Size: 50 µg
- Source: NS0
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Protein
Antibodies
ELISA Development Kit
OX40 Ligand
OX40 Ligand (OX40L/gp34/TNFSF4) is a type II transmembrane glycoprotein expressed on activated B cells, macrophages, DCs, and on endothelial cells at sites of inflammation. The receptor for OX40L, OX40, is expressed predominantly on activated CD4+ T cells. OX40L/OX40 stimulates B cell proliferation, differentiation, and immunoglobulin secretion, and promotes T cell cytokine production, proliferation, survival, and adhesion to endothelial cells. Inhibiting OX40/OX40L has beneficial effects in models of acute graft-vs-host diseases, inflammatory bowel disease, and collagen-induced arthritis.
Recombinant Mouse OX40 Ligand/TNFSF4
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Protein
Antibodies
OX40
OX40 (CD134/TNFRSF4) is expressed primarily on activated CD4+ and CD8+ T cells. In T cells, binding of OX40 by its ligand OX40L, or by agonistic antibodies, can promote clonal expansion, survival, and memory T cell development. In vivo, blockade of OX40L/OX40 interaction has been useful for treating models of autoimmune and graft-vs-host diseases, enhances the potency of vaccines, and augments anti-tumor immunity.
Recombinant Mouse OX40 (TNFRSF4)/Fc Chimera
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Antibodies
TL1A
TL1A (TNFSF15) is a type II transmembrane protein predominantly expressed on endothelial cells and is induced by TNF-alpha and IL-1 alpha. It is the longer variant of the previously cloned TL1 (also known as VEGI) which may be a cloning artifact. TL1A binds to death receptor 3 (DR3/TNFRSF25), which is expressed primarily on activated T cells. Depending on the cell context, DR3/TL1A signaling can activate the transcription factor NF-kappa B, or caspases and apoptosis.
Recombinant Human TL1A/TNFSF15
- Catalog Number: 1319-TL-010
- Size: 10 µg
- Source: E. coli
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Antibodies