The bone morphogenetic proteins (BMPs) make up a subgroup of the TGF-ß superfamily.
Their functions are mediated by binding serine/threonine kinase receptors,
and naturally occurring binding proteins can modify their activity. R&D
Systems recombinant BMP ligands and antagonists/modulators have been utilized
in many recent studies assessing several important aspects of development including
cell proliferation, differentiation, survival, and morphogenesis.
Please see our website for our complete line of TGF-ß family-related products
at: www.RnDSystems.com/go/TGFbeta
Recently Cited Products
| Ligands |
| |
Species |
Catalog |
Reference |
| BMP-2 |
H |
355-BM |
1-4 |
| BMP-4 |
H |
314-BP |
1,3-6 |
| BMP-5 |
H |
615-BM |
7 |
| BMP-6 |
H |
507-BP |
4,8,9 |
| BMP-7 |
H |
354-BP |
3-5 |
| Lefty-A |
H |
746-LF |
10 |
| |
| Antagonists/Modulators |
| |
Species |
Catalog |
Reference |
| Chordin |
M |
758-CN |
6,11 |
| Cripto-1 |
H |
145-CR |
2 |
| Follistatin |
H
M |
669-FO
769-FS |
7,12 |
| Gremlin |
M |
956-GR |
9 |
| Noggin |
M |
1967-NG |
1,3,8,14 |
| Noggin/Fe |
M |
719-NG |
6,9,11 |
| Twisted Gastrulation |
M |
756-TG |
6 |
| Key: H-Human, M-Mouse |
- Babitt, J.L. et al. (2005) Repulsive guidance molecule (RGMa),
a DRAGON homologue, is a bone morphogenetic protein co-receptor. J. Biol. Chem. 280:29820.
Sample Type: Porcine Epithelial Cells
- James, D. et al. (2005) TGFß/activin/nodal signaling is necessary
for the maintenance of pluripotency in human embryonic stem cells. Development.132:1273.
Sample Type: Human Embryonic Stem Cells
- Samad, T.A. et al. (2005) DRAGON, a Bone Morphogenetic Protein Co-receptor. J. Biol. Chem. 280:14122.
Sample Type: COS-1 Cells; Porcine Epithelial Cells; Xenopus Embryos
- Yu, P.B. et al. (2005) Bone morphogenetic protein (BMP) type
II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary
artery smooth muscle cells. J. Biol. Chem. 280:24443.
Sample Type: Mouse Pulmonary Artery Smooth Muscle Cells
- Lin, J. et al. (2005) Kielin/chordin-like protein, a novel enhancer
of BMP signaling, attenuates renal fibrotic disease. Nat. Med. 11:387.
Sample Type: Mouse Fibroblasts
- Reversade, B. & E.M. De Robertis (2005) Regulation of ADMP and BMP2/4/7
at opposite embryonic poles generates a self-regulating morphogenetic field. Cell. 123:1147.
Sample Type/Assay: Xenopus Embryo; Receptor Binding
- Pierre, A. et al. (2005) Bone morphogenetic protein 5 expression
in the rat ovary: biological effects on granulosa cell proliferation and steroidogenesis. Biol. Reprod. 73:1102.
Sample Type: Rat Granulosa Cells
- Kersten, C. et al. (2005) BMP-6 inhibits growth of mature human
B cells; induction of Smad phosphorylation and upregulation of Id1.
BMC Immunol. 6:9.
Sample Type: Human B Cells
- Winkler, D.G. et al. (2005) Sclerostin inhibition of Wnt-3a-induced
C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic
proteins. J. Biol. Chem. 280:2498.
Sample Type: Mouse Mesenchymal Cells; Mouse Fibrosarcoma Cells
- Cornet, P.B. et al. (2005) Regulation of matrix metalloproteinase-9/gelatinase
B expression and activation by ovarian steroids and LEFTY-A/endometrial bleeding-associated factor in the human endometrium. J. Clin. Endocrinol. Metab. 90:1001.
Sample Type: Human Endometrial Explants
- Keller, S. et al. (2004) Molecular recognition of BMP-2 and
BMP receptor IA. Nat. Struct. Mol. Biol. 11:481.
Sample Type/Assay: Mouse Chondrogenic Cells and Mouse Myoblast Cells; Binding Assay.
- Gore, A.J. et al. (2005) Differential regulation of follicle
stimulating hormone by activin A and TGFB1 in murine gonadotropes. Reprod. Biol. Endocrinol. 3:73.
Sample Type: Mouse Gonadotropes
- Xu, R.-E. et al. (2005) Basic FGF and suppression of BMP signaling
sustain undifferentiated proliferation of human ES cells. Nat. Methods. 2:185
Sample Type: Human Embryonic Stem Cells
|