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| Figure 1. Typical standard curve generated using R&D Systems Human PlGF
Quantikine ELISA (Catalog # DPG00). These data are for demonstration purposes
only. A standard curve should be generated for each set of samples assayed. |
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| Figure 2. Human serum, plasma, and urine samples were
assayed for PlGF using R&D Systems Human PlGF Quantikine ELISA (Catalog # DPG00). Values represent
the mean obtained from 18 or more samples each. |
Preeclampsia is a serious medical condition found in approximately 5% of pregnant
women. Although it is not usually fatal, it is characterized by hypertension,
proteinuria, and edema. Complications can include seizures, stroke, and kidney
and liver failure. Researchers have hypothesized that preeclampsia results from
an imbalance of angiogenic factors and recent studies show that serum, plasma,
and urine PlGF levels decrease significantly in women with preeclampsia and/or
those who subsequently develop the disorder.
R&D Systems Quantikine® Human PlGF ELISA is now fully-validated for
urine as well as serum, plasma, and cell culture supernate samples. This assay
has a sensitivity of less than 7 pg/mL and a dynamic range of 15.6 to 1,000
pg/mL.
Selected citations using R&D Systems Human PlGF Quantikine ELISA
in Preeclampsia Research
- Levine, R.J. et al. (2005) Urinary placental growth factor and risk
for preeclampsia. JAMA 293:77.
Sample Type: Human urine
- Lambert-Messerlian, G.M. & J.A. Canick (2004) Placenta growth factor
levels in second-trimester maternal serum in Down syndrome pregnancy and in the prediction
of preeclampsia. Prenat. Diagn. 24:876.
Sample Type: Human serum
- Levine, R.J. et al. (2004) Circulating angiogenic factors and the risk of preeclampsia. N. Engl. J. Med. 350:672.
Sample Type: Human serum
- Nagamatsu, T. et al. (2004) Cytotrophoblasts up-regulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen: an implication
for the placental vascular development and the pathophysiology of preeclampsia. Endocrinology
145:4835.
Sample Type: Human cytotrophoblast culture supernatant