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Chemokine Nomenclature

Contents

C Family

Systematic Name SYC Name Human Ligand Human Aliases Mouse Ligand Mouse Aliases Receptor
XCL1 SCYC1 Lptn SCM-1 alpha, ATAC Lptn XCR1
XCL2 SCYC2 SCM-1 beta XCR1

CX3C Family

Systematic Name SYC Name Human Ligand Human Aliases Mouse Ligand Mouse Aliases Receptor
CX3CL1 Fractalkine ABCD-3 Fractalkine CX3CR1

CC Family

Systematic Name SYC Name Human Ligand Human Aliases Mouse Ligand Mouse Aliases Receptor
CCL1 SCYA1 I-309 TCA-3 CCR8
CCL2 SCYA2 MCP-1 MCAF, HC11 JE?* CCR2
CCL3 SCYA3 MIP-1 alpha LD78 alpha, LD78 beta , GOS19, Pat464 MIP-1 alpha CCR1, CCR5
CCL4 SCYA4 MIP-1 beta pAT744, ACT-2, G-26, HC21, H400, MAD-5, LAG-1 MIP-1 beta pAT744, ACT-2, G-26, HC21, MAD-5, LAG-1 CCR5
CCL5 SCYA5 RANTES RANTES CCR1, CCR3, CCR5
CCL6 SCYA6 C10 MRP-1
CCL7 SCYA7 MCP-3 MARC MCP-3 CCR1, CCR2, CCR3
CCL8 SCYA8 MCP-2 HC14 MCP-2 CCR1, CCR2, CCR3, CCR5
CCL9/10 SCYA9 MIP-1 alpha MRP-2, CCF18 CCR1
CCL11 SCYA11 Eotaxin Eotaxin CCR3
CCL12 SCYA12 MCP-5* CCR2
CCL13 SCYA13 MCP-4 Ck beta 10,
NCC-1		 CCR1, CCR2, CCR3
CCL15 SCYA14 HCC-1 MCIF, Ck beta 1, NCC-2,CCL CCR1
CCL15 SCYA15 MIP-1 delta CC-2, MIP-5, HCC-2, NCC-3 CCR1, CCR3
CCL16 SCYA16 HCC-4 LEC, ILINK, NCC-4, LEC, LMC, CK beta 12 CCR1
CCL17 SCYA17 TARC Dendrokine TARC Dendrokine, ABCD-2 CCR4, CCR8
CCL18 SCYA18 PARC DC-CK1, AMAC-1, Ck beta 7, MIP-4, DCtactin
CCL19 SCYA19 MIP-3 beta ELC, Exodus-3, Ck beta 11 MIP-3 beta ELC, Exodus-3, Ck beta 11 CCR7
CCL20 SCYA20 MIP-3 alpha LARC, Exodus-1 MIP-3 alpha LARC, Exodus-1, ST38, CK beta 4 CCR6
CCL21 SCYA21 6Ckine Exodus-2, SLC, TCA-4, CK beta 9 6Ckine Exodus-2, SLC, TCA-4 CCR7
CCL22 SCYA22 MDC MDC DC/beta-CK CCR4
CCL23 SCYA23 MPIF Ck beta 8, Ck beta 8-1, MIP-3, MPIF-1 CCR1
CCL24 SCYA24 Eotaxin-2, MPIF-2, Ck beta 6 Eotaxin-2 MPIF-2, Ck beta 6 CCR3
CCL25 SCYA25 TECK Ck beta 15 TECK CCR9
CCL26 SCYA26 Eotaxin-3 MIP-4 alpha, IMAC, TSC-1 CCR3
CCL27 SCYA27 CTACK ILC, PESKY, ESkine, Skinkine CTACK ALP, ILC, ESkine, PESKY, Skinkine CCR10
CCL8 SCYA28 CCL28 MEC CCL28 MEC CCR10

CXC Family

Systematic Name SYC Name Human Ligand Human Aliases Mouse Ligand Mouse Aliases Receptor
CXCL1 SCYB1 GRO alpha MGSA, GRO1, NAP-3 Mouse KC CXCR2
CXCL2 SCYB2 GRO alpha, GRO beta MIP-2 alpha, GRO2 MIP-2 CXCR2
CXCL3 SCYB3 GRO gamma MIP-2 beta, GRO3 DCIP1 CXCR2
CXCL4 SCYB4 PF4 PF4
CXCL5 SCYB5 ENA-78 LIX? CXCR2
CXCL6 SCYB6 GCP-2 LIX? CXCR2
CXCL7 SCYB7 NAP-2 CTAPIII, beta-Ta, PEP TCK-1? CXCR2
CXCL8 SCYB8 IL-8 NAP-1, MDNCF, GCP-1 CXCR1, CXCR2
CXCL9 SCYB9 MIG MIG CRG-10 CXCR3
CXCL10 SCYB10 IP-10 CRG-2 IP-10 CXCR3
CXCL11 SCYB11 I-TAC beta-R1, H174, IP-9 I-TAC CXCR3
CXCL12 SCYB12 SDF-1 alpha/beta PBSF SDF-1 PBSF CXCR4
CXCL13 SCYB13 BCA-1 BLC CXCR5
CXCL14 SCYB14 BRAK BRAK Bolekine
CXCL15 SCYB15 Lungkine WECHE
CXCL16 SCYB16 CXCL16 SRPSOX CXCL16 SRPSOX CXCR6

Reference

  1. Zlotnik, A. and Yoshie, O. (2000) Immunity 12:121.

*Note: The amino acid residue identity between mJE and hMCP-1 is 55%, between mJE and hMCP-4 is 57% when the 49 aa O-glycosylated C-terminal extension is not taken into consideration. Mouse MCP-5 has a 66% aa identity with hMCP-1. Thus, the presumed relationship between mJE and hMCP-1 has been called into question. At this time, it might be best to assume that mJE is the functional ortholog of hMCP-1. Both mJE and hMCP-1 have similar activities on similar cell types. (Gu, L. et al. 1999, Chem. Immunol. 72:7.)