Articles in this issue

• Obesity-Induced Activation of the Nlrp3 Inflammasome Promotes Insulin Resistance
• Synaptic EphB2-NMDA R Dynamics: A Target for Nervous System Disease
• CXCR4: A Receptor for Extracellular Ubiquitin
• TSLP, Inflammation, & Cancer
• Recent Citations: R&D Systems Products for TGF-beta Research
• Technical Note: R&D Systems Cell Selection Kits for Cancer-associated Cells
• New Tools: Two New Methods for Creating Custom Luminex^®-based Multiplex Panels

Articles in this issue

• Milk Fat Globule-EGF Factor 8 Protein & Tissue Repair
• Ephrin-B2 Controls VEGF Receptor Endocytosis & Angiogenic Sprouting
• Interleukin-7 Inhibits Lymphocyte Apoptosis & Immunosuppression to Improve Survival in a Mouse Model of Sepsis
• A Role for Galectin-3 in Angiogenesis
• Recent Citations: R&D Systems Products for Common Cytokine Receptor gamma-Chain Family Research
• New Tools: Products for Regulatory T Cell Research
• Technical Note: A Novel Glycosyltransferase Activity Assay

Articles in this issue

• TGF-beta-Induced Epithelial-to-Mesenchymal Transition Promotes Breast Cancer Progression
• The Nlrp3 Inflammasome & IL-18 Regulate Intestinal Homeostasis
• Adiponectin Signaling: The Calcium Connection
• CCL21 & Tumor Immune Evasion
• Recent Citations: R&D Systems Products for Chemokine-related Cancer Research
• Technical Notes: R&D Systems MagCellect™ Human Blood Dendritic Cell Isolation Kit
• New Tools: Mosaic™ ELISA Human Cytokine Panel 1

Articles in this issue

• IL-27: Balancing T Cell-Mediated Immune Responses
• Vitamin D Deficiency as a Risk Factor for Multiple Sclerosis
• Developmental Apoptosis & Satellite Glial Cell Precursors
• Wnt Flips a Dual Switch to Activate Adult Neurogenesis
• Recent Citations: R&D Systems Products for Wnt-related Research
• Technical Note: R&D Systems MagCellect™ Human & Mouse Natural Killer Cell Isolation Kits
• New Tools: NEW Quantikine® ELISA Kits

Articles in this issue

• Th17 Differentiation: An Evolving Target for Multiple Sclerosis Therapy
• The Cardiovascular Effects of Midkine
• Proinflammatory Cytokines & CCR2 Promote Estrogen-deficient Bone Loss
• Soluble VEGF R2: Controlling Lymphangiogenesis
• Recent Citations: R&D Systems Products for Th17-related Research
• Technical Note: R&D Systems Antibodies & ELISAs for Cell Cycle Checkpoint Research
• New Tools: R&D Systems Proteome Profiler™ 96 Microplate-based Antibody Arrays

Articles in this issue

• TLR4: Contributing to Metabolic Syndrome in Multiple Tissues
• Differentiation Potential of Induced Pluripotent Stem Cells
• Synaptic BDNF: Connecting Physiology to Therapy
• Paradoxical Effects of CXCL14 on Tumorigenesis
• Recent Citations: R&D Systems Products for Angiogenesis Research
• Technical Note: R&D Systems Structural Characterization of the 1918 Influenza Virus Neuraminidase
• R&D Systems Human Angiogenesis Fluorokine MultiAnalyte Profiling Kit for the Luminex Platform

Articles in this issue

• CD45 in the Stem Cell Niche
• Nerve Growth Factor Receptors & Asthma
• GDNF: A Novel Treatment for Parkinson’s Disease?
• Mouse Ribs & Fly Veins: CV-2 Regulation of BMP Morphogenetic Fields
• Recent Citations: R&D Systems Products for Bone Development & Disease Research
• Technical Note: Using R&D Systems Proteome Profiler™ Antibody Arrays
• New Tools: PerCP-conjugated Antibodies

Articles in this issue

• alpha-Synuclein-based Model for Studying Parkinsons Disease Pathology
• An Active Role for Microorganisms in Controlling Intestinal Inflammation
• Osteopontin and Syndecan-4 in Liver Inflammation
• Obesity, Adipocytokines, and Breast Cancer
• Recent Citations: Neurodegenerative Disorders
• New Tools: R&D Systems Neural Toxicity Assay Kit
• Technical Note: Using NorthernLights™ Fluorescent Secondary Antibodies for Neuronal Tracing

Articles in this issue

• Chronic IL-1 beta-induced Neuroinflammation: Is it Really that Bad?
• Klotho Proteins: Novel Cofactors for Endocrine FGFs
• The Multiple Functions of IL-33
• Glypicans in Cancer
• Recent Citations: R&D Systems Products in Allergy & Asthma
• New Tools: ExactaChIP™ Chromatin IP Kits

Articles in this issue

• The Caspase-1 Inflammasome & its Role in Autoinflammatory Diseases
• Recent Citations: R&D Systems Products for Inflammasome Research
• New Tools: R&D Systems NEW PlusCellect™ Kits for Positive Cell Selection
• Technical Note: IL-17 Family Antibodies for Flow Cytometry

Articles in this issue

• The TGF-beta Superfamily
• TGF-beta Superfamily Signaling in ES cells (Mice are Not Men)
• BMP-1 Regulation of TGF-beta Activity
• Co-receptor Regulation of TGF-beta Signaling
• Recent Citations: GDNF Family & Receptors
• Technical Notes: The Quantikine® ELISA in Establishing a Role for Endoglin in Preeclampsia
• New Tools: Cell-Based ELISAs

Articles in this issue

• HIF-1 & Vascular Development
• Adiponectin & Apoptotic Cell Clearance
• Chemokines & Pregnancy
• Dkk-1: Upsetting the Balance in Rheumatoid Arthritis
• Recent Citations: R&D Systems Products in Neuroscience-Related Research
• New Tools: Recombinant Active Protein Kinases
• Technical Notes: R&D Systems Is With You Every Step of the Way – Analyzing Proteins of Interest

Articles in this issue

• MMP-12 in Smoking-Related Pulmonary Disease
• Regulation of VE-Cadherin and VEGF R2 by VEGF
• Sonic Hedgehog: A Morphogen Involved in Axon Guidance
• Taking Advantage of Notch in Stem Cell Expansion
• Recent Citations: Leptin & Leptin Receptor
• Technical Notes: Assessing the Pluripotent Status of Stem Cells
• New Tools: Recombinant Proteases of the Renin-Angiotensin System (RAS)

Articles in this issue

• Oncomodulin: The inflammatory response and nerve regeneration
• Vasohibin: A negative regulator of angiogenesis
• Estrogen & the Immune System: Of mice and women (and nitric oxide)
• Sending Wnt on its Way
• Recent Citations: Recombinant Proteins: Neuronal Outgrowth, Survival, and Guidance
• New tools: Multianalyte Profiling Fluorokine MAP Multiplex Adhesion Panel
• Technical Notes: Technical Service Frequently Asked Questions

Articles in this issue

• ADMP: A Ventralizing BMP in the Dorsal Embryo
• sFRP-4: Phosphate, is there a limit?
• Stanniocalcin-1: Phosphate...on the other hand
• A novel role for the nervous system in HSPC mobilization
• News: R&D Systems cIAP-1 & cIAP-2 Antibodies Beat the Competition
• Recent Citations: Recombinant BMPs & Modulators
• Technical Notes: beta-Catenin Research Tools
• New tools: GPCR Research Reagents

Articles in this issue

• An Updated Model of Anthrax Toxin Function
• HMGB1: Sounding the Alarm
• Fractalkine Signaling Modulates Neurotoxicity in vivo
• PBEF/Visfatin: A Role in Metabolic Syndrome, but What Is It?
• New Tools: NorthernLights™ New Fluorescent Secondary Antibodies
• Technical Notes: B7 Family Research Tools

Articles in this issue

• Need help at the cell surface? Ask your local sheddase.
• Ephrin-B2: A Receptor for Henipaviruses
• Wnt: A polarizing factor in early mouse development
• FGF-21: From Cloning to Clinic
• Recent Citations: Recombinant Mouse Wnt-3a & Wnt-5a
• News: R&D Systems Stem Cell Antibodies Recognized
• New Tools: Parameter™ Kits: A New Line of Small Molecule Assays

Articles in this issue

• Novel Caspase-8 Roles Revealed by Knockouts
• Chemokines & Anti-tumor Immune Responses
• The ErbB Family - Talk and Crosstalk
• Ryk: a Wnt Co-receptor at the Intersection of Frizzled & Dishevelled
• New Tools: Nuclear Hormone Receptor Antibodies
• Technical Notes: Human Mesenchymal Stem Cell Functional Identification Kit

Articles in this issue

• Feeder-free Stem Cells
• Glycated Insulin
• C-Reactive Protein
• New Tools: PlGF ELISA for Preeclampsia Research
• Technical Notes: MagCellect Cell Selection Kits for Stem Cell Research

Articles in this issue

• The Early History of TGF-beta
• Recent Advances In TGF-beta Research
• New Tools: TGF-beta Superfamily Products

Articles in this issue

• Fish-Oil: A Novel Anti-Inflammatory Mechanism
• BDGI/OKL38: A New Breast Cancer Target
• The SLAM Family
• Cysteine-rich Repeats: What Are They Good For?
• New Tools: Axon Outgrowth & Guidance

Articles in this issue

• ACE-2: The SARS Receptor Identified
• Adiponectin & Type 2 Diabetes
• ChemR23: An Orphan Adopted
• T. gondii: A Therapeutic Agent for HIV-1?
• New Tools: Sepsis Research
• Technical Notes: MagCellect

Articles in this issue

• T Cells Made Easy: T Cells from Embryonic Stem Cells
• Parturition & Sufactant Protein A
• Akt Modulates TGF-beta Activities
• Airway Remodeling & Eosinophils
• LYVE-1: Functions & Use as a Lymphatic Marker
• New Tools: Phospho-Tyrosine Antibodies
• Technical Notes: Wnt Inhibitor Activity

Articles in this issue

• p53: More than a Transcription Factor?
• MicroRNAs Regulate Mammalian Hematopoiesis
• Erythropoietin: Good or Bad for Cancer?
• Macrophage Activation
• New Tools: for the Platelet-Derived Growth Factor
• Technical Notes: Proteases for Complement Research

Articles in this issue

• Can a Committed B Cell Become a Macrophage?
• VEGF & Amyotrophic Lateral Sclerosis
• Osteoclast Co-Stimulation
• Gene Expression in the Aging Brain
• New Tools: Human Tissue Kallikrein Products
• Technical Notes: MycoProbe® Mycoplasma Detection

Articles in this issue

• FKBP38: A New Piece in the Apoptosis Puzzle
• IL-21: A New Regulator of NK Cell Activity
• IGFBP-4 and Bone
• Sick About HMG-1
• LRP Signaling
• Notch Signaling
• New Tools: Cystatin C, Galectin-3, & Rae-1 beta
• Technical Notes: RSK1, Phosphorylation at S380

Articles in this issue

• VEGF R3 Marks a New Class of Endothelial Stem Cells
• Wnt-3a Helps the Segmentation Clock Tick
• Glomerulonephritis: Beyond Inflammation
• A Role for Sonic Hedgehog in Axon Guidance
• New Tools: For Developmental Research
• Technical Notes: Antibodies to Complex Antigens

Articles in this issue

• IL-12: Cell Protection from UVB
• New IL-1 Family Member Elicits Anti-tumor Immunity
• COX-3: The Acetaminophen Target Finally Revealed
• Neural Stem Cells: A Glioma Magic Bullet?
• The Cholinergic Anti-Inflammatory Pathway
• New Tools: Recombinant TNF Superfamily Proteins
• Technical Notes: Serum Levels of Vascular Growth Factors During Pregnancy

Articles in this issue

• Bacillus anthracis vs. Dendritic Cells
• NCAM as a Novel GDNF Family Receptor
• CTLA-4: Hiding in Plain Sight
• Chemokine Receptors and Multiple Sclerosis Pathogenesis
• AgRP & Syndecan-3
• New Tools: Proteases & Inhibitors
• Technical Notes: phospho-specific ELISAs

Articles in this issue

• Defensins and Antitumor Immunity
• GDF-8
• Galectins
• New Tools: Cathepsins
• Technical Notes: Assay Precision Impact of Salivary Cytokine Contamination

Articles in this issue

• DEC-205 and Antigen Presentation
• Wnt Signaling and sFRPs
• Cathepsin L
• Cytokines - Pieces of the Autism Puzzle
• RELT: A New Member of the Tumor Necrosis Factor
• Technical Notes: CCR7

Articles in this issue

• TGF-alpha: A New Job for an Old Friend
• Novel IL-1 Family Members
• ABCG2, A Better Alternative Than CD34?
• TREM-1 Mediates Sepsis
• Role of IL-6 in Energy Expenditure

Articles in this issue

• Eotaxin Stimulates Eosinophil Release of Preformed IL-4
• OSM Induction of Chondrocyte MMP and TIMP-3 Gene Expression
• Cotton Rat
• Interleukin 20
• IL-10 and IL-12 Influence in Dendritic Cell Maturation
• Human Interleukin 20 Receptor Subunits
• New Tools: for Alzheimers Disease Research
• Technical Notes: Multi-Cytokine Profiling

Articles in this issue

• BMPs Influence FSH Synthesis
• Regakine-1: An Abundant Serum Chemokine
• SDF-1 Effect on Hematopoietic Progenitor and Stem Cell Mobilization
• TIQ and Parkinsons Disease
• FISP (IL-4-induced Secreted Protein)
• Lipid-modified Sonic Hedgehog (Shh)
• New Tools: For Development Research

Articles in this issue

• Immunosuppression: A Role for Statins
• BAFF and APRIL Involvement in B Cell Development
• Cytokines and Overtraining
• IL-23: A New Composite Cytokine
• CLF: CLC Complex: A Second Ligand for the CNTF Receptor
• Technical Notes: Detection of Apoptosis with Double Labeling: TUNEL and Active Caspase-3
• New Tools: Active MMP Activity Assays

Articles in this issue

• Fetal Alcohol Syndrome and Apoptosis
• Limitin: A New Cytokine Inhibitor of B-cell Development
• Ephrin-A1 and Melanoma Progression
• Osteopontin Involvement in Cell-mediated Immunity
• TNF Homologue Implicated in Systemic Lupus Erythematosus (SLE)
• MMP Modulation of Cytokines
• Technical Notes: CFTR Monoclonal Antibodies

Articles in this issue

• BACE Implicated in Alzheimers Amyloid Production
• Innate Immunity and the Toll-like Receptor Family
• Bone Morphogenetic Protein 6
• Activated T Cells Mediate Bone Loss Through OPGL/TRANCE
• Growth/Differentiation Factor 5
• New Tools: Cell and Tissue Staining Kits
• Technical Notes: Caspase Antibodies

Articles in this issue

• DC-SIGN: Friend or Foe?
• Insulin-Like Growth Factors and Cancer
• Presenilin 1: gamma-secretase or a gamma-secretase Cofactor
• TNF R Pre-Ligand-Binding Assembly Domain
• Fractalkine in Glomerulonephritis
• New Tools: DermaTACS
• Technical Notes: ELISpot

Articles in this issue

• VEGF, Angiopoietin-2 and Tumor Vascularization
• The Search for Tie-1 and Tie-2 Ligands
• An Inhibitor of Fas Ligand-induced Apoptosis
• Aggrecanase, a Target for Arthritis Therapy?
• Telomerase
• Targeted Gene Transfer with Fluorokines™
• New Tools: DePsipher™

Articles in this issue

• Cytokine Upregulation of HIV Coreceptors
• The Interleukin 13 Receptor Complex
• SODD - Silencer of Death Domains
• Dendritic Cells: A New Immunotherapy?
• Potential Role for NGF in Breast Cancer
• Anti-Cytokine Antibodies: Induced and Autoantibodies
• Immunotoxin-induced Apoptosis
• Technical Notes: Intracellular Cytokine Staining

Articles in this issue

• Cytokine Signalling and Nuclear Localization
• Soluble MHC Molecules as T Cell Staining Reagents
• IL-4 and IL-5 Regulate the Allergic Response in NFAT1 Deficiency
• BMPs
• Viral Cytokines
• Bax Relocates from the Cytosol to the Mitochondria to Trigger Apoptosis
• TRAIL and its Receptors

Articles in this issue

• Chemokines Induce Moesin Interaction with ICAM-3
• IGF-II, Developmental Abnormalities and Genomic Imprinting
• Substance P: A Modulator of Inflammation
• IL-8 and Metastasis
• Apoptosis: Mitochondria Accused of Murder
• Eph Receptors and Ephrins
• Chemiluminescent ELISAs
• Plasma ICAM-1 is Correlated with Increased Risk of Cardiovascular Disease
• New Tools: Leptin Immunoassays
• QuantiGlo IL-6 Immunoassay

Articles in this issue

• The Role of MCP-1 in Atherosclerosis
• TNF-alpha Genetic Variations in Disease
• HGF/SF Activation of Integrins
• Cytokines in the Nervous System
• Apoptosis: Caspase Pathways
• New Angiogenic Factors
• New Tools: Quantikine mRNA
• Technical Notes: TACS-XL in situ Apoptosis Detection Kits

Articles in this issue

• LIF in Reproduction
• Control of Immune Responses via CD28 and CTLA-4
• SDF-1 in Hematopoiesis
• MCP-4 and Mouse MCP-5: New C-C Chemokines
• TGF-beta 2 Antisense Gene Therapy for Glioblastoma
• Cytokine-related Mechanisms of Apoptosis
• Heparan Sulfate Proteoglycans on Leukocytes
• Immunohistochemical Analysis of Cytokines using Cytokine Affinity-purified Antibodies
• Inflammation & Cardiovascular Disease

Articles in this issue

• IL-17 is Produced by T-Cells
• A New IFN-gamma-Inducing Factor
• Ischemia/Reperfusion Injury
• Free Radicals and Oxidative Stress
• Fibroblast Growth Factors and their Receptors
• Cytokines Suppress HIV Replication
• Technical Notes: Human IL-12 Immunoassay