Products

Research Topics

Immunoglobulin Superfamily CAMs

The Ig superfamily CAMs are calcium-independent transmembrane glycoproteins. Each Ig superfamily CAM has an extracellular domain, which contains several Ig-like intra-chain disulfide-bonded loops with conserved cysteine residues, a transmembrane domain, and an intracellular domain that interacts with the cytoskeleton. Typically, cell adhesion molecules bind integrins or other Ig superfamily CAMs. The neuronal CAMs have been implicated in neuronal patterning. Endothelial cell adhesion molecules play an important role in immune response and inflammation. Members of the Ig superfamily include the intercellular adhesion molecules (ICAMs), vascular-cell adhesion molecule (VCAM-1), platelet-endothelial-cell adhesion molecule (PECAM-1), neural-cell adhesion molecule (NCAM), and more.

ALCAM/CD166
 

AMICA
 

ASAM
 

BCAM
 

BOC
 

CD31/PECAM-1
 

CDO
 

CEACAM
 

Contactins

DSCAM
 

ESAM
 

HepaCAM
 

IGSF4/SynCAM Family

Intercellular Adhesion Molecules (ICAMs)
 

JAMs (Junctional Adhesion Molecules)

Kilon
 

Kirrel Family
 

L1 Family

LAMP
 

MAdCAM-1
 

MAM Domain-Containing GPI Anchor Proteins (MDGAs)

MCAM
 

NCAM

OBCAM
 

VCAM-1
 

Other Immunoglobulin Superfamily CAMs