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B Cell Markers

The production of mature B cells occurs through a series of processes that take place in the bone marrow, spleen, and other peripheral lymphoid organs. Clusters of Differentiation (CD) proteins are a group of cell surface markers that can be used to identify different stages of B cell development or activation, including progenitor B cells, pro-B cells, pre-B cells, immature B cells, transitional 1 B cells, transitional 2 B cells, marginal zone B cells, naïve mature follicular B cells, activated germinal center B cells, memory B cells, plasmablast cells, and plasma cells. Other cell surface markers used to identify specific stages of B cell development or activation are also listed.



Progenitor B Cell

Pro-B Cell
 

Pre-B Cell
 

Immature B Cell
 

Transitional 1 B Cell

Transitional 2 B Cell

Marginal Zone B Cell

Naive Mature Follicular B Cell

Activated Germinal Center B Cell

Memory B Cell
 

Plasmablast
 

Plasma Cell