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IL-6: Products


Interleukin 6 (IL-6), also known as interferon-beta 2, 26 kDa protein and B cell stimulatory factor-2 (BSF-2), is a pleiotropic α-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism, and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22 kDa - 28 kDa phosphorylated and variably glycosylated molecule. Mature human IL-6 is 183 amino acids (aa) in length and shares 41% aa sequence identity with mouse and rat IL-6. Alternate splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties.

IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R, triggering IL-6 R association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R are generated by both alternate splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R elicit responses from gp130-expressing cells that lack cell surface IL-6 R. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R is predominantly restricted to hepatocytes, leukocytes, and lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R but not from other cytokines that utilize gp130 as a coreceptor.



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DESCRIPTIONANTIBODY
APPLICATION (KEY)
CATALOG #
SIZEPRICEQTY 
Human IL-6 Quantikine ELISA Kit D6050 1 Kit $505
Human IL-6 Quantikine PharmPak (50 Plates) PD6050 1 Pack Please Inquire  
Human IL-6 Quantikine SixPak (6 Plates) S6050 1 Pack $2,419
Human IL-6 Quantikine HS ELISA Kit HS600B 1 Kit $599
Human IL-6 Quantikine HS PharmPak (50 Plates) PHS600B 1 Pack Please Inquire  
Human IL-6 Quantikine HS SixPak (6 Plates) SS600B 1 Pack $2,875
Recombinant Human IL-6 206-IL-010 10 µg $229
Recombinant Human IL-6 206-IL-050 50 µg $729
Recombinant Human IL-6 206-IL-200 200 µg $1,010
Recombinant Human IL-6, CF 206-IL-001MG/CF 1 mg $3,400
Recombinant Human IL-6, CF 206-IL-010/CF 10 µg $229
Recombinant Human IL-6, CF 206-IL-050/CF 50 µg $729
Recombinant Human IL-6, CF 206-IL-200/CF 200 µg $1,010
Mouse IL-6 Quantikine ELISA Kit, 2 Plate M6000B 1 Kit $629
Mouse IL-6 Quantikine PharmPak (50 Plates) PM6000B 1 Pack Please Inquire  
Mouse IL-6 Quantikine SixPak (6 Plates) SM6000B 1 Pack $1,509
Recombinant Mouse IL-6 406-ML-005 5 µg $235
Recombinant Mouse IL-6 406-ML-025 25 µg $765
Recombinant Mouse IL-6 406-ML-200 200 µg $1,400
Recombinant Mouse IL-6, CF 406-ML-005/CF 5 µg $235
Recombinant Mouse IL-6, CF 406-ML-025/CF 25 µg $765
Recombinant Mouse IL-6, CF 406-ML-200/CF 200 µg $1,400
Human IL-6 DuoSet, 15 Plate DY206 1 Kit $649
Proteome Profiler Mouse Cytokine Array Kit, Panel A
Contains 4 membranes - each spotted in duplicate with 40 different cytokine antibodies
ARY006 1 Kit $499
Proteome Profiler Human Cytokine Array Kit, Panel A
Contains 4 membranes - each spotted in duplicate with 36 different cytokine antibodies
ARY005 1 Kit $499
Mouse IL-6 DuoSet, 15 Plate DY406 1 Kit $649
Rat IL-6 Quantikine ELISA Kit R6000B 1 Kit $479
Rat IL-6 Quantikine PharmPak (50 Plates) PR6000B 1 Pack Please Inquire  
Rat IL-6 Quantikine SixPak (6 Plates) SR6000B 1 Pack $2,299
Human IL-6 MAb (Clone 6708), Mouse IgG1 B/N, ELISA(Cap), WB MAB206 500 µg $335
Human IL-6 Affinity Purified Polyclonal Ab, Goat IgG WB, B/N, ICC AF-206-NA 100 µg $365
Human IL-6 QuantiGlo ELISA Kit Q6000B 1 Kit $599
Human IL-6 QuantiGlo PharmPak (50 Plates) PQ6000B 1 Pack Please Inquire  
Human IL-6 QuantiGlo SixPak (6 Plates) SQ6000B 1 Pack $2,875
Mouse IL-6 Biotinylated Affinity Purified PAb, Goat IgG WB, ELISA(Det) BAF406 50 µg $420
Human Luminex Screening Assay LXSAH 1 Kit Build Now  
Mouse IL-6 MAb (Clone MP5-20F3), Rat IgG1 ELISA(Cap), WB, B/N MAB406 500 µg $335
Porcine IL-6 Quantikine ELISA Kit P6000B 1 Kit $479
Mouse IL-6 Affinity Purified Polyclonal Ab, Goat IgG B/N, WB, ICC AF-406-NA 100 µg $365
Rat IL-6 Affinity Purified Polyclonal Ab, Goat IgG WB, ICC, B/N AF506 100 µg $365
Proteome Profiler Mouse Angiogenesis Array Kit
Contains 4 membranes - each spotted in duplicate with 53 different cytokine antibodies
ARY015 1 Kit $599
Human IL-6 Biotinylated Affinity Purified PAb, Goat IgG ELISA(Det), WB, ICC BAF206 50 µg $390
Proteome Profiler Rat Cytokine Array Kit, Panel A
Contains 4 membranes - each spotted in duplicate with 29 different cytokine antibodies
ARY008 1 Kit $499
Rat IL-6 DuoSet, 15 Plate DY506 1 Kit $649
Human IL-6 Luminex Performance Assay LUH206 1 Kit $175
Proteome Profiler Mouse Adipokine Array Kit
Contains 4 membranes - each spotted in duplicate with 38 different obesity-related antibodies
ARY013 1 Kit $499
Recombinant Rat IL-6 506-RL-010 10 µg $205
Recombinant Rat IL-6 506-RL-050 50 µg $649
Recombinant Rat IL-6, CF 506-RL-010/CF 10 µg $205
Recombinant Rat IL-6, CF 506-RL-050/CF 50 µg $649