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TGF-beta 1: Products


Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.



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DESCRIPTIONANTIBODY
APPLICATION (KEY)
CATALOG #
SIZEPRICEQTY 
Recombinant Human TGF-beta 1 240-B-002 2 µg $255
Recombinant Human TGF-beta 1 240-B-010 10 µg $809
Recombinant Human TGF-beta 1, CF 240-B-001MG/CF 1 mg $13,500
Recombinant Human TGF-beta 1, CF 240-B-002/CF 2 µg $255
Recombinant Human TGF-beta 1, CF 240-B-010/CF 10 µg $809
Human TGF-beta 1 Quantikine ELISA Kit DB100B 1 Kit $505
Human TGF-beta 1 Quantikine PharmPak (50 Plates) PDB100B 1 Pack Please Inquire  
Human TGF-beta 1 Quantikine SixPak (6 Plates) SB100B 1 Pack $2,419
Human TGF-beta 1 100-B-001 1 µg $289
Human TGF-beta 1 100-B-010 10 µg $1,729
Human TGF-beta 1, CF 100-B-001/CF 1 µg $289
Human TGF-beta 1, CF 100-B-010/CF 10 µg $1,729
Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit MB100B 1 Kit $505
Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine PharmPak
50 Plates
PMB100B 1 Pack Please Inquire  
Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine SixPak SMB100B 1 Pack $2,419
Proteome Profiler Human Angiogenesis Array Kit
Contains 4 membranes - each spotted in duplicate with 55 different cytokine antibodies
ARY007 1 Kit $599
Human TGF-beta 1 DuoSet, 15 Plate DY240 1 Kit $649
TGF-beta 1 MAb (Clone 9016), Mouse IgG1 ELISA(Cap), IHC, FC, WB, B/N MAB240 500 µg $335
Recombinant Mouse TGF-beta 1 7666-MB-005 5 µg $355
Recombinant Mouse TGF-beta 1, CF 7666-MB-005/CF 5 µg $355
Mouse TGF-beta 1 DuoSet, 15 Plate DY1679 1 Kit $649
TGF-beta 1,-2,-3 Luminex Performance Assay 3-plex Kit
For the measurement of TGF-beta 1, TGF-beta 2, and TGF-beta 3
LKT001 1 Kit $799
Porcine TGF-beta 1 101-B1-001 1 µg $255
Porcine TGF-beta 1 101-B1-010 10 µg $1,589
Porcine TGF-beta 1, CF 101-B1-001/CF 1 µg $255
Porcine TGF-beta 1, CF 101-B1-010/CF 10 µg $1,589
TGF-beta Pan Specific Polyclonal Ab, Rabbit IgG WB, B/N AB-100-NA 1 mg $435
Recombinant Human Latent TGF-beta 1 299-LT-005 5 µg $289
Recombinant Human Latent TGF-beta 1 299-LT-025 25 µg $799
Recombinant Human Latent TGF-beta 1, CF 299-LT-005/CF 5 µg $289
Recombinant Human Latent TGF-beta 1, CF 299-LT-025/CF 25 µg $799
TGF-beta 1 Biotinylated Affinity Purified PAb, Chicken IgY ELISA(Det), WB BAF240 50 µg $390
TGF-beta 1/1.2 Affinity Purified Polyclonal Ab, Chicken IgY WB, B/N AF-101-NA 100 µg $399
Recombinant Human TGF-beta 1, ACFP ACFP240 25 µg $2,405
Recombinant Human TGF-beta 1 (Human Cell-expressed) 7754-BH-005 5 µg $255
Recombinant Human TGF-beta 1 (Human Cell-expressed) 7754-BH-025 25 µg $809
Recombinant Human TGF-beta 1 (Human Cell-expressed), CF 7754-BH-005/CF 5 µg $255
Recombinant Human TGF-beta 1 (Human Cell-expressed), CF 7754-BH-025/CF 25 µg $809
Human TGF-beta 1 Biotinylated Fluorokine Kit NFTG0 1 Kit $599
TGF-beta 1,-2,-3 Phycoerythrin MAb (Clone 1D11), Mouse IgG1 FC IC1835P 100 Tests $305
TGF-beta 1,-2,-3 Allophycocyanin MAb (Clone 1D11), Mouse IgG1 FC IC1835A 100 Tests $349
Human TGF-beta 1 Phycoerythrin MAb (Clone 9016), Mouse IgG1 FC IC240P 100 Tests $305
Human Latent TGF-beta 1 ELISpot Development Module SEL246 1 Kit $465
TGF-beta 1 MAb (Clone 141322), Mouse IgG2B WB MAB2401 500 µg $335
Human TGF-beta 1 Allophycocyanin MAb (Clone 9016), Mouse IgG1 FC IC240A 100 Tests $349
TGF-beta 1/1.2 Polyclonal Ab, Chicken IgY B/N, WB AB-101-NA 1 mg $435
Human TGF-beta 1 Fluorescein MAb (Clone 9016), Mouse IgG1 FC IC240F 100 Tests $225
Human Latent TGF-beta 1 ELISpot Kit EL246 1 Kit $445
Human Latent TGF-beta 1 ELISpot SixPak (6 Plates) XEL246 1 Pack $1,870
Mouse TGF-beta 1 DuoSet, 5 Plate DY1679-05 1 Kit $249