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ULBP-2: Products

ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. The name ULBP derives from the original identification of three proteins, ULBP-1, -2, and -3, as ligands for the human cytomegalovirus glycoprotein UL16; they were designated UL16 binding proteins (ULBP). The genes for ULBPs reside in a cluster of ten related genes, six of which encode potentially functional glycoproteins. ULBP-2 has also been described under the names RaeT1H (retinoic acid early transcript), NKG2DL2, and ALCAN-alpha. ULBP-5 is also known as RaeT1G and ULBP-6 is also known as RaeT1L. These proteins are distantly related to MHC class I proteins, but they possess only the alpha 1 and alpha 2 Ig-like domains, and they have no capacity to bind peptide or interact with beta 2-Microglobulin. Some family members, including ULBP-2, are anchored to the membrane via a GPI-linkage, whereas others have transmembrane domains. Engagement of NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. The ULBPs are expressed on some tumor cells and have been implicated in tumor surveillance. Over aa 26-217, ULBP-2 shares 92% and 95% aa sequence identity with the human ULBP-5 and ULBP-6, respectively.

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Human ULBP-2/5/6 Phycoerythrin MAb (Clone 165903), Mouse IgG2A Flow FAB1298P 100 Tests $349
Human ULBP-2/5/6 MAb (Clone 165903), Mouse IgG2A B/N, Flow MAB1298 500 µg $339
Human ULBP-2/5/6 MAb (Clone 165903), Mouse IgG2A B/N, Flow MAB1298-SP 25 µg $99
Human ULBP-2 DuoSet, 15 Plate DY1298 1 Kit (for 15 Plates) $649
Human ULBP-2/5/6 Affinity Purified Polyclonal Ab, Goat IgG B/N, IHC, WB AF1298 100 µg $359
Human ULBP-2/5/6 Affinity Purified Polyclonal Ab, Goat IgG B/N, IHC, WB AF1298-SP 25 µg $99
Human ULBP-2/5/6 Allophycocyanin MAb (Clone 165903), Mouse IgG2A Flow FAB1298A 100 Tests $389
Recombinant Human ULBP-2 Fc Chimera, CF 1298-UL-050 50 µg $329
Human ULBP-2/5/6 Biotinylated Affinity Purified PAb, Goat IgG WB BAF1298 50 µg $390
Human ULBP-2/5/6 PerCP MAb (Clone 165903), Mouse IgG2A Flow FAB1298C 100 Tests $399
Human ULBP-2 (NP_079493) VersaClone cDNA RDC0822 10 µg $199