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Conversion Table for World Health Organization (WHO) Standards

The unit status of WHO material is dependent on the testing performed. Further information regarding WHO standards can be found on the NIBSC website (http://www.nibsc.ac.uk/catalog/standards/intro.html).



R&D Systems Cytokine R&D Systems Catalog Number WHO Standard Cytokine WHO Standard Reference Number WHO Standard Units/µg Cell Line used for Bioassay R&D Systems Cytokine 1 µg = WHO units Unit Status
rhActivin A 338-AC rhActivin A 91/626 1 K562 1 RU
rhBMP-2 355-BM rhBMP-2 93/574 500 ATDC-5 960 IU
rhEGF 236-EG rhEGF 91/530 1.0 x 103 Balb-3T3 3.2 x 103 IU
rhEpo 286-EP rhEpo 87/684 124.64 TF-1 1 U = 1.2 WHO U IU
rhFGF basic 233-FB rhFGF basic 90/712 800 NR6R-3T3 800 IU
rhFlt-3 Ligand 308-FK rhFlt-3 Ligand 96/532 1.0 x 103 Baflt 3.1 x 103 RU
rhG-CSF 214-CS rhG-CSF 88/502 1.0 x 105 NFS-60 2.6 x 105 IU
rhGM-CSF 215-GM rhGM-CSF 88/646 1.0 x 104 TF-1 1.5 x 104 IU
rmGM-CSF 415-ML rmGM-CSF 91/658 1.0 x 105 DA3 3.5 x 105 RU
rhGRO alpha 275-GR rhGRO alpha 92/722 1.0 x 105 PMN 2.11 x 105 RU
rhHGF 294-HG rhHGF 96/564 1 4MBr-5 2.0 IU
rhIFN-gamma 285-IF hIFN-gamma
rhIFN-gamma
rhIFN-gamma
rhIFN-gamma 		82/587
85/534
87/586
88/606 (CHO) 		NA
2.0 x 104
2.0 x 104
1.9 x 104		 HeLa 6.8 x 103
2.0 x 104
2.0 x 104
2.0 x 104 		IU
RU
RU
IU
rmIFN-gamma 485-MI rmIFN-gamma NIHGg02-901-533 1.0 x 103 L929 8.43 x 103 IU
rhIGF-I 291-G1 rhIGF-I 91/554 1 MCF-7 1 IU
rhIGF-II 292-G2 rhIGF-II 96/538 1 MCF-7 0.85 IU
rhIL-1 alpha 200-LA rhIL-1 alpha 86/632 1.0 x 105 D10.G4.1 1.6 x 105 IU
rmIL-1 alpha 400-ML rmIL-1 alpha 93/672 1.0 x 106 D10.G4.1 7.1 x 105 RU
rhIL-1 beta 201-LB rhIL-1 beta
rhIL-1 beta 		86/552
86/680 		1.1 x 105
1.0 x 105 		D10.G4.1 2.0 x 105 IU
IU
rmIL-1 beta 401-ML rmIL-1 beta 93/668 1.0 x 106 D10.G4.1 1.1 x 106 RU
rhIL-2 202-IL hIL-2
rhIL-2 		86/504
86/564 		NA
13202.6 		CTLL-2 2.4 x 103
1.3 x 104 		IU
NIBSC*
rmIL-2 402-ML rmIL-2 93/566 1.0 x 105 CTLL-2 2.5 x 105 RU
rhIL-3 203-IL rhIL-3
rhIL-3 		88/780
91/510		 1.0 x 103
1.7 x 103 		TF-1 2.4 x 103
2.3 x 104		 RU
IU
rmIL-3 403-ML rmIL-3 91/662 1.0 x 105 NFS-6 1.7 x 105 RU
rhIL-4 204-IL rhIL-4 88/656 1.0 x 104 TF-1 2.9 x 104 IU
rmIL-4 404-ML rmIL-4 91/656 1.0 x 104 HT-2 1.8 x 105 RU
rhIL-5 205-IL rhIL-5 90/586 1.0 x 104 TF-1 4.4 x 104 RU
rhIL-6 206-IL rhIL-6
rhIL-6		 88/514
89/548		 5.0 x 103
1.0 x 105		 T1165.85.2.1 7.0 x 103
1.1 x 105		 RU
IU
rmIL-6 406-ML rmIL-6 93/730 1.0 x 105 T1165.85.2.1 9.0 x 105 RU
rhIL-7 207-IL rhIL-7 90/530 1.0 x 105 activated PBL 2.4 x 105 IU
rmIL-7 407-ML rmIL-7 93/740 5.0 x 104 activated PBL RU
rhIL-8 208-IL rhIL-8 89/520 1.0 x 103 PMN see below** IU
rhIL-9 209-IL rhIL-9 91/678 1.0 x 104 MO7e 8.4 x 103 RU
rmIL-9 409-ML rmIL-9 93/504 NA TS1 0.9 µg NA
rhIL-10 217-IL rhIL-10
rhIL-10		 92/516
93/722		 5.0 x 103
5.0 x 103		 MC/9 2.9 x 104
1.45 x 104		 RU
RU
rhIL-11 218-IL rhIL-11
rhIL-11		 92/522
92/788		 NA
1.0 x 104		 T11 0.4 µg
1.2 x 104		 NA
RU
rhIL-12 219-IL rhIL-12 95/544 1.0 x 104 PBL 1.24 x 104 IU
rhIL-13 rhIL-13 94/622 1.0 x 103 TF-1 780 RU
rhIL-15 247-IL rhIL-15 95/554 1.0 x 104 MO7e 4.5 x 105 RU
rhM-CSF 216-MC rhM-CSF 89/512 6.0 x 104 M-NFS-60 1.5 x 105 IU
rhMCP-1 279-MC rhMCP-1 92/794 1.0 x 103 MNC 1.36 x 103 RU
rhMCP-2 281-CP rhMCP-2 96/594 2.5 x 103 MNC see below** RU
rhMIP-1 alpha 270-LD rhMIP-1 alpha 92/518 100 MNC 200 RU
rhMIP-1 beta 271-BME rhMIP-1 beta 96/588 1.0 x 103 MNC 1.6 x 103 RU
rhß-NGF 256-GF rhß-NGF 93/556 1.0 x 103 TF-1 1.0 x 103 RU
rhOSM 295-OM rhOSM 93/564 5.0 x 104 TF-1 6.2 x 104 RU
rhPDGF-BB 220-BB rhPDGF-BB 94/728 750 NR6R-3T3 1.94 x 103 RU
rhProlactin 682-PL rhProlactin 84/500 0.0212 Nb2-11 0.054 IU
rhRANTES 278-RN rhRANTES 92/520 1.0 x 104 MNC 2.5 x 104 RU
rhSCF 255-SC rhSCF 91/682
92/514		 1.0 x 103
NA		 TF-1
TF-1		 1.2 x 103
1.4 µg		 RU
NA
porcine TGF-beta 1 101-B1 bTGF-beta 1 89/516 18750 HT-2 2.1 x 104 RU
porcine TGF-beta 2 102-B2 hTGF-beta 2 90/696 2.0 x 104 HT-2 5.6 x 104 RU
rhTGF-beta 240-B rhTGF-beta 1 89/514 6000 HT-2 3.2 x 104 RU
rhTNF-alpha 210-TA rhTNF-alpha 88/786 4.0 x 104 L-929 1.1 x 105 IU
rmTNF-alpha 410-MT rmTNF-alpha 88/532 2.0 x 105 L-929 2.7 x 105 RU
rhTNF-beta 211-TB rhTNF-beta 87/640 1.5 x 105 L-929 4.6 x 104 IU

* Calibrated against the WHO 1st International Standard for human IL-2

** In side by side evaluation of this standard with R&D Systems product, the standard demonstrated much lower maximal signal and thus cannot be compared using ED50