Technical Information
Conversion Table for World Health Organization (WHO) Standards
The unit status of WHO material is dependent on the testing performed. Further information regarding WHO standards can be found on the NIBSC website.
| R&D Systems Cytokine |
R&D Systems Catalog Number |
WHO Standard Cytokine |
WHO Standard Reference Number |
WHO Standard Units/µg |
Cell Line used for Bioassay |
R&D Systems Cytokine 1 µg = WHO units |
Unit Status |
| rhActivin A |
338-AC |
rhActivin A |
91/626 |
1 |
K562 |
1 |
RU |
| rhBMP-2 |
355-BM |
rhBMP-2 |
93/574 |
500 |
ATDC-5 |
960 |
IU |
| rhEGF |
236-EG |
rhEGF |
91/530 |
1.0 x 103 |
Balb-3T3 |
3.2 x 103 |
IU |
| rhEpo |
286-EP |
rhEpo |
87/684 |
124.64 |
TF-1 |
1 U = 1.2 WHO U |
IU |
| rhFGF-7 |
251-KG |
rhFGF-7 |
03/148 |
900 |
4MBr-5 |
520 |
RU |
| rhFGF basic |
233-FB |
rhFGF basic |
90/712 |
800 |
NR6R-3T3 |
800 |
IU |
| rhFSH |
5925-FS |
rhFSH |
92/642 |
13.8 |
HEK293/h FSH R |
17.5 |
IU |
| rhFlt-3 Ligand |
308-FK |
rhFlt-3 Ligand |
96/532 |
1.0 x 103 |
Baflt |
3.1 x 103 |
RU |
| rhG-CSF |
214-CS |
rhG-CSF |
88/502 |
1.0 x 105 |
NFS-60 |
2.6 x 105 |
IU |
| rhGH |
1067-GH |
h GH |
80/505 |
2.6 x 10-3 |
Nb2-11 |
5.4 x 10-3 |
IU |
| rhGM-CSF |
215-GM |
rhGM-CSF |
88/646 |
1.0 x 104 |
TF-1 |
1.5 x 104 |
IU |
| rmGM-CSF |
415-ML |
rmGM-CSF |
91/658 |
1.0 x 105 |
DA3 |
3.5 x 105 |
RU |
| rhGRO alpha |
275-GR |
rhGRO alpha |
92/722 |
1.0 x 105 |
PMN |
2.11 x 105 |
RU |
| rhHGF |
294-HG |
rhHGF |
96/564 |
1 |
4MBr-5 |
2.0 |
IU |
| rhIFN-gamma |
285-IF |
hIFN-gamma
rhIFN-gamma
rhIFN-gamma
rhIFN-gamma |
82/587
85/534
87/586
88/606 (CHO) |
NA
2.0 x 104
2.0 x 104
1.9 x 104 |
HeLa |
6.8 x 103
2.0 x 104
2.0 x 104
2.0 x 104 |
IU
RU
RU
IU |
| rmIFN-gamma |
485-MI |
rmIFN-gamma |
NIHGg02-901-533 |
1.0 x 103 |
L929 |
8.43 x 103 |
IU |
| rhIGF-I |
291-G1 |
rhIGF-I |
1/554 |
1 |
MCF-7 |
1 |
IU |
| rhIGF-II |
292-G2 |
rhIGF-II |
96/538 |
1 |
MCF-7 |
0.85 |
IU |
| rhIL-1 alpha |
200-LA |
rhIL-1 alpha |
86/632 |
1.0 x 105 |
D10.G4.1 |
1.6 x 105 |
IU |
| rmIL-1 alpha |
400-ML |
rmIL-1 alpha |
93/672 |
1.0 x 106 |
D10.G4.1 |
7.1 x 105 |
RU |
| rhIL-1 beta |
201-LB |
rhIL-1 beta
rhIL-1 beta |
86/552
86/680 |
1.1 x 105
1.0 x 105 |
D10.G4.1 |
2.0 x 105 |
IU
IU |
| rmIL-1 beta |
401-ML |
rmIL-1 beta |
93/668 |
1.0 x 106 |
D10.G4.1 |
1.1 x 106 |
RU |
| rhIL-1ra |
280-RA |
rhIL-1ra |
92/644 |
1.0 x 10-3 |
D10.G4.1 |
1.0 x 10-3 |
RU |
| rhIL-2 |
202-IL |
hIL-2
rhIL-2 |
86/504
86/564 |
NA
13202.6 |
CTLL-2 |
2.4 x 103
1.3 x 104 |
IU
NIBSC* |
| rmIL-2 |
402-ML |
rmIL-2 |
93/566 |
1.0 x 105 |
CTLL-2 |
2.5 x 105 |
RU |
| rhIL-3 |
203-IL |
rhIL-3
rhIL-3 |
88/780
91/510 |
1.0 x 103
1.7 x 103 |
TF-1 |
2.4 x 103
2.3 x 104 |
RU
IU |
| rmIL-3 |
403-ML |
rmIL-3 |
91/662 |
1.0 x 105 |
NFS-6 |
1.7 x 105 |
RU |
| rhIL-4 |
204-IL |
rhIL-4 |
88/656 |
1.0 x 104 |
TF-1 |
2.9 x 104 |
IU |
| rmIL-4 |
404-ML |
rmIL-4 |
91/656 |
1.0 x 104 |
HT-2 |
1.8 x 105 |
RU |
| rhIL-5 |
205-IL |
rhIL-5 |
90/586 |
1.0 x 104 |
TF-1 |
4.4 x 104 |
RU |
| rhIL-6 |
206-IL |
rhIL-6
rhIL-6 |
88/514
89/548 |
5.0 x 103
1.0 x 105 |
T1165.85.2.1 |
7.0 x 103
1.1 x 105 |
RU
IU |
| rmIL-6 |
406-ML |
rmIL-6 |
93/730 |
1.0 x 105 |
T1165.85.2.1 |
9.0 x 105 |
RU |
| rhIL-7 |
207-IL |
rhIL-7 |
90/530 |
1.0 x 105 |
activated PBL |
2.4 x 105 |
IU |
| rmIL-7 |
407-ML |
rmIL-7 |
93/740 |
5.0 x 104 |
activated PBL |
1.5 x 105 |
RU |
| rhIL-8 |
208-IL |
rhIL-8 |
89/520 |
1.0 x 103 |
PMN |
see below** |
IU |
| rhIL-9 |
209-IL |
rhIL-9 |
91/678 |
1.0 x 104 |
MO7e |
8.4 x 103 |
RU |
| rmIL-9 |
409-ML |
rmIL-9 |
93/504 |
NA |
TS1 |
0.9 µg |
NA |
| rhIL-10 |
217-IL |
rhIL-10
rhIL-10 |
92/516
93/772 |
5.0 x 103
5.0 x 103 |
MC/9 |
2.9 x 104
1.45 x 104 |
RU
RU |
| rhIL-11 |
218-IL |
rhIL-11
rhIL-11 |
92/522
92/788 |
NA
1.0 x 104 |
T11 |
0.4 µg
1.2 x 104 |
NA
RU |
| rhIL-12 |
219-IL |
rhIL-12 |
95/544 |
1.0 x 104 |
PBL |
1.24 x 104 |
IU |
| rhIL-13 |
|
rhIL-13 |
94/622 |
1.0 x 103 |
TF-1 |
780 |
RU |
| rhIL-15 |
247-IL |
rhIL-15 |
95/554 |
1.0 x 104 |
MO7e |
4.5 x 105 |
RU |
| rhLeptin |
398-LP |
rhLeptin |
97/594 |
800 |
BaF3/h OB R |
1.2 x 103 |
IU |
| rmLeptin |
498-OB |
rmLeptin |
97/626 |
1.0 x 103 |
BaF3/h OB R |
1.7 x 103 |
IU |
| rhM-CSF |
216-MC |
rhM-CSF |
89/512 |
6.0 x 104 |
M-NFS-60 |
1.5 x 105 |
IU |
| rhMCP-1 |
279-MC |
rhMCP-1 |
92/794 |
1.0 x 103 |
MNC |
1.36 x 103 |
RU |
| rhMCP-2 |
281-CP |
rhMCP-2 |
96/594 |
2.5 x 103 |
MNC |
see below** |
RU |
| rhMIP-1 alpha |
270-LD |
rhMIP-1 alpha |
92/518 |
100 |
MNC |
200 |
RU |
| rhMIP-1 beta |
271-BME |
rhMIP-1 beta |
96/588 |
1.0 x 103 |
MNC |
1.6 x 103 |
RU |
| rhbeta-NGF |
256-GF |
rhbeta-NGF |
93/556 |
1.0 x 103 |
TF-1 |
1.0 x 103 |
RU |
| rhOSM |
295-OM |
rhOSM |
93/564 |
5.0 x 104 |
TF-1 |
6.2 x 104 |
RU |
| rhPDGF-BB |
220-BB |
rhPDGF-BB |
94/728 |
750 |
NR6R-3T3 |
1.94 x 103 |
RU |
| rhProlactin |
682-PL |
rhProlactin |
84/500 |
0.0212 |
Nb2-11 |
0.054 |
IU |
| rhRANTES |
278-RN |
rhRANTES |
92/520 |
1.0 x 104 |
MNC |
2.5 x 104 |
RU |
| rhSCF |
255-SC |
rhSCF |
91/682
92/514 |
1.0 x 103
NA |
TF-1
TF-1 |
1.2 x 103
1.4 µg |
RU
NA |
| porcine TGF-beta 1 |
101-B1 |
bTGF-beta 1 |
89/516 |
18750 |
HT-2 |
2.1 x 104 |
RU |
| porcine TGF-beta 2 |
102-B2 |
hTGF-beta 2 |
90/696 |
2.0 x 104 |
HT-2 |
5.6 x 104 |
RU |
| rhTGF-beta |
240-B |
rhTGF-beta 1 |
89/514 |
6000 |
HT-2 |
3.2 x 104 |
RU |
| rhTGF-beta 3 |
243-B3 |
rhTGF-beta 3 |
98/608 |
1.0 x 104 |
HT-2 |
2.5 x 104 |
RU |
| rhTNF-alpha |
210-TA |
rhTNF-alpha |
87/650 |
4.0 x 104 |
L-929 |
1.1 x 105 |
IU |
| rmTNF-alpha |
410-MT |
rmTNF-alpha |
88/532 |
2.0 x 105 |
L-929 |
2.7 x 105 |
RU |
| rhTNF-beta |
211-TB |
rhTNF-beta |
87/640 |
1.5 x 105 |
L-929 |
4.6 x 104 |
IU |
| rhTRAIL |
375-TEC(E. coli) |
rhTRAIL |
04/166 |
1.0 x 104 |
L-929 |
5.6 x 103 |
IU |
| rhTRAIL |
375-TL(NS0) |
rhTRAIL |
04/166 |
1.0 x 104 |
L-929 |
3.2 x 103 |
IU |
| rhTSH |
4610-TH |
rhTSH |
94/674 |
6.7 x 10-3 |
HEK293/h TSH R |
7.9 x 10-3 |
RU |
| rhVEGF165 |
293-VE |
rhVEGF165 |
02/286 |
1.0 x 103 |
HUVEC |
1.1 x 103 |
RU |
* Calibrated against the WHO 1st International Standard for human IL-2
** In side by side evaluation of this standard with R&D Systems product, the standard demonstrated much lower maximal signal and thus cannot be compared using ED50