WHO Unit Conversion
The unit status of WHO material is dependent on the testing performed. Further information regarding WHO standards can be found on the NIBSC website (http://www.nibsc.ac.uk/catalog/standards/intro.html).
| R&D Systems Cytokine |
R&D Systems Catalog Number |
WHO Standard Cytokine |
WHO Standard Reference Number |
WHO Standard Units/µg |
Cell Line used for Bioassay |
R&D Systems Cytokine 1 µg = WHO units |
Unit Status |
| rhActivin A |
338-AC |
rhActivin A |
91/626 |
1 |
K562 |
1 |
RU |
| rhBMP-2 |
355-BM |
rhBMP-2 |
93/574 |
500 |
ATDC-5 |
960 |
IU |
| rhEGF |
236-EG |
rhEGF |
91/530 |
1.0 x 103 |
Balb-3T3 |
3.2 x 103 |
IU |
| rhEpo |
286-EP |
rhEpo |
87/684 |
124.64 |
TF-1 |
1 U = 1.2 WHO U |
IU |
| rhFGF basic |
233-FB |
rhFGF basic |
90/712 |
800 |
NR6R-3T3 |
800 |
IU |
| rhFlt-3 Ligand |
308-FK |
rhFlt-3 Ligand |
96/532 |
1.0 x 103 |
Baflt |
3.1 x 103 |
RU |
| rhG-CSF |
214-CS |
rhG-CSF |
88/502 |
1.0 x 105 |
NFS-60 |
2.6 x 105 |
IU |
| rhGM-CSF |
215-GM |
rhGM-CSF |
88/646 |
1.0 x 104 |
TF-1 |
1.5 x 104 |
IU |
| rmGM-CSF |
415-ML |
rmGM-CSF |
91/658 |
1.0 x 105 |
DA3 |
3.5 x 105 |
RU |
| rhGRO alpha |
275-GR |
rhGRO alpha |
92/722 |
1.0 x 105 |
PMN |
2.11 x 105 |
RU |
| rhHGF |
294-HG |
rhHGF |
96/564 |
1 |
4MBr-5 |
2.0 |
IU |
| rhIFN-gamma |
285-IF |
hIFN-gamma
rhIFN-gamma
rhIFN-gamma
rhIFN-gamma |
82/587
85/534
87/586
88/606 (CHO) |
NA
2.0 x 104
2.0 x 104
1.9 x 104 |
HeLa |
6.8 x 103
2.0 x 104
2.0 x 104
2.0 x 104 |
IU
RU
RU
IU |
| rmIFN-gamma |
485-MI |
rmIFN-gamma |
NIHGg02-901-533 |
1.0 x 103 |
L929 |
8.43 x 103 |
IU |
| rhIGF-I |
291-G1 |
rhIGF-I |
91/554 |
1 |
MCF-7 |
1 |
IU |
| rhIGF-II |
292-G2 |
rhIGF-II |
96/538 |
1 |
MCF-7 |
0.85 |
IU |
| rhIL-1 alpha |
200-LA |
rhIL-1 alpha |
86/632 |
1.0 x 105 |
D10.G4.1 |
1.6 x 105 |
IU |
| rmIL-1 alpha |
400-ML |
rmIL-1 alpha |
93/672 |
1.0 x 106 |
D10.G4.1 |
7.1 x 105 |
RU |
| rhIL-1 beta |
201-LB |
rhIL-1 beta
rhIL-1 beta |
86/552
86/680 |
1.1 x 105
1.0 x 105 |
D10.G4.1 |
2.0 x 105 |
IU
IU |
| rmIL-1 beta |
401-ML |
rmIL-1 beta |
93/668 |
1.0 x 106 |
D10.G4.1 |
1.1 x 106 |
RU |
| rhIL-2 |
202-IL |
hIL-2
rhIL-2 |
86/504
86/564 |
NA
13202.6 |
CTLL-2 |
2.4 x 103
1.3 x 104 |
IU
NIBSC* |
| rmIL-2 |
402-ML |
rmIL-2 |
93/566 |
1.0 x 105 |
CTLL-2 |
2.5 x 105 |
RU |
| rhIL-3 |
203-IL |
rhIL-3
rhIL-3 |
88/780
91/510 |
1.0 x 103
1.7 x 103 |
TF-1 |
2.4 x 103
2.3 x 104 |
RU
IU |
| rmIL-3 |
403-ML |
rmIL-3 |
91/662 |
1.0 x 105 |
NFS-6 |
1.7 x 105 |
RU |
| rhIL-4 |
204-IL |
rhIL-4 |
88/656 |
1.0 x 104 |
TF-1 |
2.9 x 104 |
IU |
| rmIL-4 |
404-ML |
rmIL-4 |
91/656 |
1.0 x 104 |
HT-2 |
1.8 x 105 |
RU |
| rhIL-5 |
205-IL |
rhIL-5 |
90/586 |
1.0 x 104 |
TF-1 |
4.4 x 104 |
RU |
| rhIL-6 |
206-IL |
rhIL-6
rhIL-6 |
88/514
89/548 |
5.0 x 103
1.0 x 105 |
T1165.85.2.1 |
7.0 x 103
1.1 x 105 |
RU
IU |
| rmIL-6 |
406-ML |
rmIL-6 |
93/730 |
1.0 x 105 |
T1165.85.2.1 |
9.0 x 105 |
RU |
| rhIL-7 |
207-IL |
rhIL-7 |
90/530 |
1.0 x 105 |
activated PBL |
2.4 x 105 |
IU |
| rmIL-7 |
407-ML |
rmIL-7 |
93/740 |
5.0 x 104 |
activated PBL |
|
RU |
| rhIL-8 |
208-IL |
rhIL-8 |
89/520 |
1.0 x 103 |
PMN |
see below** |
IU |
| rhIL-9 |
209-IL |
rhIL-9 |
91/678 |
1.0 x 104 |
MO7e |
8.4 x 103 |
RU |
| rmIL-9 |
409-ML |
rmIL-9 |
93/504 |
NA |
TS1 |
0.9 µg |
NA |
| rhIL-10 |
217-IL |
rhIL-10
rhIL-10 |
92/516
93/772 |
5.0 x 103
5.0 x 103 |
MC/9 |
2.9 x 104
1.45 x 104 |
RU
RU |
| rhIL-11 |
218-IL |
rhIL-11
rhIL-11 |
92/522
92/788 |
NA
1.0 x 104 |
T11 |
0.4 µg
1.2 x 104 |
NA
RU |
| rhIL-12 |
219-IL |
rhIL-12 |
95/544 |
1.0 x 104 |
PBL |
1.24 x 104 |
IU |
| rhIL-13 |
|
rhIL-13 |
94/622 |
1.0 x 103 |
TF-1 |
780 |
RU |
| rhIL-15 |
247-IL |
rhIL-15 |
95/554 |
1.0 x 104 |
MO7e |
4.5 x 105 |
RU |
| rhM-CSF |
216-MC |
rhM-CSF |
89/512 |
6.0 x 104 |
M-NFS-60 |
1.5 x 105 |
IU |
| rhMCP-1 |
279-MC |
rhMCP-1 |
92/794 |
1.0 x 103 |
MNC |
1.36 x 103 |
RU |
| rhMCP-2 |
281-CP |
rhMCP-2 |
96/594 |
2.5 x 103 |
MNC |
see below** |
RU |
| rhMIP-1 alpha |
270-LD |
rhMIP-1 alpha |
92/518 |
100 |
MNC |
200 |
RU |
| rhMIP-1 beta |
271-BME |
rhMIP-1 beta |
96/588 |
1.0 x 103 |
MNC |
1.6 x 103 |
RU |
| rhß-NGF |
256-GF |
rhß-NGF |
93/556 |
1.0 x 103 |
TF-1 |
1.0 x 103 |
RU |
| rhOSM |
295-OM |
rhOSM |
93/564 |
5.0 x 104 |
TF-1 |
6.2 x 104 |
RU |
| rhPDGF-BB |
220-BB |
rhPDGF-BB |
94/728 |
750 |
NR6R-3T3 |
1.94 x 103 |
RU |
| rhProlactin |
682-PL |
rhProlactin |
84/500 |
0.0212 |
Nb2-11 |
0.054 |
IU |
| rhRANTES |
278-RN |
rhRANTES |
92/520 |
1.0 x 104 |
MNC |
2.5 x 104 |
RU |
| rhSCF |
255-SC |
rhSCF |
91/682
92/514 |
1.0 x 103
NA |
TF-1
TF-1 |
1.2 x 103
1.4 µg |
RU
NA |
| porcine TGF-beta 1 |
101-B1 |
bTGF-beta 1 |
89/516 |
18750 |
HT-2 |
2.1 x 104 |
RU |
| porcine TGF-beta 2 |
102-B2 |
hTGF-beta 2 |
90/696 |
2.0 x 104 |
HT-2 |
5.6 x 104 |
RU |
| rhTGF-beta |
240-B |
rhTGF-beta 1 |
89/514 |
6000 |
HT-2 |
3.2 x 104 |
RU |
| rhTNF-alpha |
210-TA |
rhTNF-alpha |
87/640 |
4.0 x 104 |
L-929 |
1.1 x 105 |
IU |
| rmTNF-alpha |
410-MT |
rmTNF-alpha |
88/532 |
2.0 x 105 |
L-929 |
2.7 x 105 |
RU |
| rhTNF-beta |
211-TB |
rhTNF-beta |
87/640 |
1.5 x 105 |
L-929 |
4.6 x 104 |
IU |
* Calibrated against the WHO 1st International Standard for human IL-2
** In side by side evaluation of this standard with R&D Systems product, the standard demonstrated much lower maximal signal and thus cannot be compared using ED50