Evaluating New 3-D Systems for Disease Modeling, Drug Validation, and Toxicology

Wednesday, May 30, 2018 - 16:31

Cell and tissue-based models are a necessary step in the workflow for toxicology testing, drug discovery*, and disease modeling. In recent years, the research and pharmaceutical industries have adopted more complex ex vivo and in vitro 3-D tissue models because of their better predictive power. The first part of this webinar discusses the history of cell- and tissue-based models systems for toxicology, drug validation, and disease modeling. Particular emphasis will be placed on culture methods and optimization of stem cell-based models and 3-D cell culture systems, including organoids. The second half of the webinar introduces MimEX Tissue Model Systems, a transformative culturing platform that builds upon the physiological and structural advancements of current organoid models by producing 3-D tissue with better accessibility and lower variability. The power of this platform will be demonstrated using stem cells isolated from human gastrointestinal tract (MimEX GI) as an example of various epithelial tissues that can be modeled using system.

Key Topics:

  • History of cell and tissue model systems for toxicology and disease modeling
  • Troubleshooting variability in induced pluripotent stem cell-based models
  • Advantages and disadvantages of current 3-D culture systems
  • Workflow solutions to support 3-D culturing
  • New 3-D culturing platforms

View Optimizing Organoid Culture Conditions: The Importance of Growth Factor Bioactivity and Reagent Consistency Application Note

Download our eBook: Evolution of Model Systems for Toxicology, Drug Screening, and Disease Modeling

View our Organoid Reagent Guide

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View Tools for Stem Cell Research


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