Evaluating New 3-D Systems for Disease Modeling, Drug Validation, and Toxicology

Cell and tissue-based models are a necessary step in the workflow for toxicology testing, drug discovery*, and disease modeling. In recent years, the research and pharmaceutical industries have adopted more complex ex vivo and in vitro 3-D tissue models because of their better predictive power. The first part of this webinar discusses the history of cell- and tissue-based models systems for toxicology, drug validation, and disease modeling. Particular emphasis will be placed on culture methods and optimization of stem cell-based models and 3-D cell culture systems, including organoids. The second half of the webinar introduces MimEX^™ Tissue Model Systems, a transformative culturing platform that builds upon the physiological and structural advancements of current organoid models by producing 3-D tissue with better accessibility and lower variability. The power of this platform will be demonstrated using stem cells isolated from human gastrointestinal tract (MimEX^™ GI) as an example of various epithelial tissues that can be modeled using system.

Key Topics:

• History of cell and tissue model systems for toxicology and disease modeling
• Troubleshooting variability in induced pluripotent stem cell-based models
• Advantages and disadvantages of current 3-D culture systems
• Workflow solutions to support 3-D culturing
• New 3-D culturing platforms

View Optimizing Organoid Culture Conditions: The Importance of Growth Factor Bioactivity and Reagent Consistency Application Note

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