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Evaluating New 3-D Systems for Disease Modeling, Drug Validation, and Toxicology
Wednesday, May 30, 2018 - 16:31
Cell and tissue-based models are a necessary step in the workflow for toxicology testing, drug discovery*, and disease modeling. In recent years, the research and pharmaceutical industries have adopted more complex ex vivo and in vitro 3-D tissue models because of their better predictive power. The first part of this webinar discusses the history of cell- and tissue-based models systems for toxicology, drug validation, and disease modeling. Particular emphasis will be placed on culture methods and optimization of stem cell-based models and 3-D cell culture systems, including organoids. The second half of the webinar introduces MimEX™ Tissue Model Systems, a transformative culturing platform that builds upon the physiological and structural advancements of current organoid models by producing 3-D tissue with better accessibility and lower variability. The power of this platform will be demonstrated using stem cells isolated from human gastrointestinal tract (MimEX™ GI) as an example of various epithelial tissues that can be modeled using system.
History of cell and tissue model systems for toxicology and disease modeling
Troubleshooting variability in induced pluripotent stem cell-based models
Advantages and disadvantages of current 3-D culture systems