T Cell Subsets
T helper type 1 (Th1) cells are required for host defense against intracellular viral and bacterial pathogens. The most common markers used to identify Th1 cells are IFN-gamma production and expression of the T-bet transcription factor. For more information on Th1 cells, please see our main Th1 Cell Research Topic Page.
T helper type 2 (Th2) cells are important for... More Info
Airway Inflammation In Asthma
Asthma is a complex disease with serious complications of inflammation and airway constriction. Many allergens are proteolytically active and can degrade adhesion molecules in epithelial cell tight junctions. Protease activated receptors (PARs) and microbial antigen activated TLRs trigger inflammatory cytokine release. Particulate or gaseous pollutants such as cigarette smoke, diesel exhaust,... More Info