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T Cell Subsets

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View Larger T helper type 1 (Th1) cells are required for host defense against intracellular viral and bacterial pathogens. The most common markers used to identify Th1 cells are IFN-gamma production and expression of the T-bet transcription factor. For more information on Th1 cells, please see our main Th1 Cell Research Topic Page. T helper type 2 (Th2) cells are important for...

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Airway Inflammation In Asthma

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Asthma is a complex disease with serious complications of inflammation and airway constriction. Many allergens are proteolytically active and can degrade adhesion molecules in epithelial cell tight junctions. Protease activated receptors (PARs) and microbial antigen activated TLRs trigger inflammatory cytokine release. Particulate or gaseous pollutants such as cigarette smoke, diesel exhaust,...

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A Look Inside A Tumor: Mechanisms of Tumor Evasion and Immunosuppression in the Tumor Microenvironment

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View Larger Abnormal cells such as tumor cells are typically recognized and eliminated by the immune system. Immune cells such as natural killer (NK) cells, natural killer T (NKT) cells, and gamma delta T cells provide the first line of defense against tumor cells by exerting direct cytotoxic effects and secreting high levels of IFN-gamma to promote tumor cell destruction. Under these...

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