"402-IL" has 421 results in Resources.

Featured Literature Inflammasomes: Intracellular Regulators of Pathogen Recognition, Host Defense, and Inflammation Poster View Poster Featured Products Products for IL-1 Family Research Brochure View Brochure   Overview of the IL-1 Family Signaling Pathway The IL-1 cytokine family consists of eleven...

Until recently, there were four members of the IL-1 family: IL-1 alpha, IL-1 beta, IL-1ra and IL-18. Six additional members of this family have since been described based on conservation of amino acid (aa) sequence, identity of gene structure, and three-dimensional structure. All of the new genes map to the region of chromosome 2 between the IL-1 beta and IL-1ra loci,1 thus suggesting that each...

The IL-17 family of cytokines consists of six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by a number of different cell types and primarily promote pro-inflammatory immune responses. Cytokines belonging to the IL-17 family are secreted as dimers and bind to members of the IL-17 receptor family. The IL-17 receptor family includes IL-17 R/IL-17RA,...

First Printed in R&D Systems 2003 Catalog Contents Introduction Novel IL-1 Ligands References Introduction The term IL-1 is generally used to describe IL-1 alpha and IL-1 beta, both of which exercise the same biological effects. Along with IL-1ra and IL-18, these molecules play important roles in both innate and adaptive immunity. View Larger Image Figure 1. Schematic...

View IL-17 FamilySignaling Pathways The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. Members of this family have a highly conserved C-terminus containing a cysteine-knot fold structure. Most IL-17 proteins are secreted as disulfide-linked dimers, with the exception of IL-17B, which...

Several laboratories recently identified new IL-1 and IL-1 receptor family members from EST databases that share sequence similarity with known family members.1-3 A unifying nomenclature has been adopted for the IL-1 family in which the ten members have been designated IL-1F1 to IL-1F10.2 Likewise, IL-1 receptor family members have been assigned the systematic designation IL-1 R1 to IL-1 R9...

View IL-1 FamilySignaling Pathway The IL-1 family of cytokines consists of eleven members (IL-1F1-IL-1F11) that share a conserved beta-trefoil structure and bind to receptors belonging to the IL-1 receptor family. With the exception of IL-1ra/IL-1F3, IL-1 family cytokines lack a signal peptide and therefore, are not thought to be secreted by the conventional endoplasmic...

View IL-12 Family Signaling Pathways The IL-12 family of cytokines includes five members, IL-12, IL-23, IL-27, IL-35, and IL-39, which are alll heterodimeric cytokines consisting of an alpha chain subunit (p19, p28, or p35) paired with a beta chain subunit (p40 or EBI3). Both IL-12 and IL-23 are disulfide-linked dimers consisting of the p40 beta chain linked to either the p35 alpha chain to form...

Fig. 1. IL-23 is a biologically active cytokine composed of two subunits: p19 and the p40 subunit of IL-12 (panel A). IL-23 binds specifically to the IL-12 R beta 1 subunit and can stimulate IFN-gamma production and proliferation in PHA blast T cells and activated CD45RO (memory) T cells (panel B). p19 is a novel four-alpha helix cytokine that is most closely related in...

Overview of IL-27 p28/IL-30 Signaling Pathways IL-27 p28/IL-30 is a member of the IL-6 cytokine family, which also includes IL-6, IL-11, IL-31, Leukemia inhibitory factor (LIF), Oncostatin M (OSM), Cardiotrophin-like cytokine (CLC), Ciliary neurotrophic factor (CNTF), Cardiotrophin-1 (CT-1), and Neuropoietin. IL-27 p28, also known as IL-30, is a four-helix bundle cytokine that associates with...