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"402-IL" has 383 results in Resources.

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IL-1 Family Signaling Pathways

Pathways

The IL-1 cytokine family consists of eleven members that play important roles in regulating inflammation. Members include IL-1 alpha, IL-1 beta, IL-1ra, IL-18, IL-33, IL-36Ra, IL-36 alpha, IL-36 beta, IL-36 gamma, IL-37, and IL-38. While most of these cytokines are biologically active as full-length molecules, activation and secretion of IL-1 beta and IL-18 requires...

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Novel IL-1 Family Members

Article

Until recently, there were four members of the IL-1 family: IL-1 alpha, IL-1 beta, IL-1ra and IL-18. Six additional members of this family have since been described based on conservation of amino acid (aa) sequence, identity of gene structure, and three-dimensional structure. All of the new genes map to the region of chromosome 2 between the IL-1 beta and IL-1ra loci,1 thus suggesting that each...

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IL-17 Family Signaling Pathways

Pathways

The IL-17 family of cytokines consists of six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by a number of different cell types and primarily promote pro-inflammatory immune responses. Cytokines belonging to the IL-17 family are secreted as dimers and bind to members of the IL-17 receptor family. The IL-17 receptor family includes IL-17 R/IL-17RA,...

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Interleukin-1 Family: Ligands & Receptors

Article

First Printed in R&D Systems 2003 Catalog Contents Introduction Novel IL-1 Ligands References Introduction The term IL-1 is generally used to describe IL-1 alpha and IL-1 beta, both of which exercise the same biological effects. Along with IL-1ra and IL-18, these molecules play important roles in both innate and adaptive immunity. View Larger Image Figure 1. Schematic...

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IL-17 Family

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View IL-17 FamilySignaling Pathways The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. Members of this family have a highly conserved C-terminus containing a cysteine-knot fold structure. Most IL-17 proteins are secreted as disulfide-linked dimers, with the exception of IL-17B, which...

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IL-1 Family

Research Areas

View IL-1 FamilySignaling Pathway The IL-1 family of cytokines consists of eleven members (IL-1F1-IL-1F11) that share a conserved beta-trefoil structure and bind to receptors belonging to the IL-1 receptor family. With the exception of IL-1ra/IL-1F3, IL-1 family cytokines lack a signal peptide and therefore, are not thought to be secreted by the conventional endoplasmic...

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IL-1 Family Member Elicits Anti-tumor Immunity

Article

Several laboratories recently identified new IL-1 and IL-1 receptor family members from EST databases that share sequence similarity with known family members.1-3 A unifying nomenclature has been adopted for the IL-1 family in which the ten members have been designated IL-1F1 to IL-1F10.2 Likewise, IL-1 receptor family members have been assigned the systematic designation IL-1 R1 to IL-1 R9...

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IL-12 Family

Research Areas

View IL-12 Family Signaling Pathways The IL-12 family of cytokines includes five members, IL-12, IL-23, IL-27, IL-35, and IL-39, which are alll heterodimeric cytokines consisting of an alpha chain subunit (p19, p28, or p35) paired with a beta chain subunit (p40 or EBI3). Both IL-12 and IL-23 are disulfide-linked dimers consisting of the p40 beta chain linked to either the p35 alpha chain to form...

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IL-23: A New Composite Cytokine

Article

Fig. 1. IL-23 is a biologically active cytokine composed of two subunits: p19 and the p40 subunit of IL-12 (panel A). IL-23 binds specifically to the IL-12 R beta 1 subunit and can stimulate IFN-gamma production and proliferation in PHA blast T cells and activated CD45RO (memory) T cells (panel B). p19 is a novel four-alpha helix cytokine that is most closely related in...

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Technical Note: IL-17 Family Antibodies for Flow Cytometry

Article

R&D Systems has added several new fluorochrome-conjugated antibodies for the Interleukin 17 (IL-17) family of ligands and receptors. IL-17 family ligands are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions, most notably allergic responses. The six members, IL-17, IL-17B, IL-17C, IL-17D, IL-17E (also known as IL-25), and...

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