Cancer Immunotherapy Dendritic Cell Subsets
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Plasmacytoid dendritic cells (pDC) reside in the circulation, extravasate to inflammatory sites, and traffic to draining lymph nodes to initiate adaptive immune responses. Mature pDC induce T cell survival, Th1 bias, cytotoxic T lymphcyte (CTL) activity, natural killer cell (NK) cytotolytic activity, maturation of myeloid DC, and development of plasma cells. They are efficient at antigen...
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Modified Chemokines Exhibit Altered Potency and Specificity
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Chemokines are small secreted proteins that function in leukocyte trafficking, recruitment, and activation and have a role in many pathophysiological processes such as infectious and autoimmune diseases, inflammation, cancer, and vascular disease.
Naturally occurring modifications, such as N-terminal truncation, can affect the biological potency and the receptor specificity of chemokines.
R&D...
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Human Cytokine Array Kit
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Human Cytokine Array Kit, Panel A Ordering Information
Introduction
R&D Systems Human Cytokine Array, Panel A (Catalog # ARY005) is a rapid, sensitive, and economical tool used to simultaneously detect the relative levels of 36 different cytokines, chemokines, and acute phase proteins in a single sample. No specialized equipment is necessary.
Sample Data
Product Insert (PDF,...
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Mouse Cytokine Antibody Array, Panel A
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Mouse Cytokine Antibody Array, Panel A Ordering Information
Introduction
R&D Systems Mouse Cytokine Array, Panel A (Catalog # ARY006) is a rapid, sensitive, and economical tool used to simultaneously detect the relative levels of 40 different cytokines, chemokines, and more in a single sample. No specialized equipment is necessary
Sample Data
Product Insert (PDF, 116K)
Protocol...
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Cancer Immunotherapy: Dendritic Cell Isolation/Expansion
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Expand your dendritic cell (DC) cultures with our CellXVivo™ Human Monocyte-derived DC Differentiation Kit with an optimized protocol and optimized reagents. Or you can use our specially-designed StemXVivo® Serum-Free Dendritic Cell Base Media supplemented with our high-quality recombinant Cytokines and Growth Factors. For DC vaccine preparation with more rigorous documentation, take advantage...
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Multiple Sclerosis: Immune Cell Access to the Central Nervous System
Article
First Published in R&D Systems' 2006 Catalog
Contents
Multiple Sclerosis
Etiology
Pathology
Blood-Brain Barrier
Adhesion Molecules
Tight Junctions
Selectins
Ig Superfamily Cell Adhesion Molecules
ICAM-1
VCAM-1
PECAM-1
Integrins
alphaLbeta2/LFA-1
alpha4beta1/VLA-4
Chemokines
Chemokine Receptors
Matrix Metalloproteinases
MMP-9
Conclusion
Multiple sclerosis...
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Immune Checkpoint Blockade: Blocking Antibodies
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Blockade of immune checkpoint molecules, such as CTLA-4 and PD-1/PD-L1, is a promising therapeutic approach for cancer treatment. Unfortunately, blocking CTLA-4 or PD-1/PD-L1 is not universally successful across different cancer types and patients. It is thought that co-targeting multiple checkpoint molecules simultaneously could improve the effectiveness of this strategy. Take...
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