Cancer Immunotherapy Dendritic Cell Subsets
Plasmacytoid dendritic cells (pDC) reside in the circulation, extravasate to inflammatory sites, and traffic to draining lymph nodes to initiate adaptive immune responses. Mature pDC induce T cell survival, Th1 bias, cytotoxic T lymphcyte (CTL) activity, natural killer cell (NK) cytotolytic activity, maturation of myeloid DC, and development of plasma cells. They are efficient at antigen... More Info
Modified Chemokines Exhibit Altered Potency and Specificity
Chemokines are small secreted proteins that function in leukocyte trafficking, recruitment, and activation and have a role in many pathophysiological processes such as infectious and autoimmune diseases, inflammation, cancer, and vascular disease.
Naturally occurring modifications, such as N-terminal truncation, can affect the biological potency and the receptor specificity of chemokines.
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Mouse Cytokine Antibody Array, Panel A
Mouse Cytokine Antibody Array, Panel A Ordering Information
R&D Systems Mouse Cytokine Array, Panel A (Catalog # ARY006) is a rapid, sensitive, and economical tool used to simultaneously detect the relative levels of 40 different cytokines, chemokines, and more in a single sample. No specialized equipment is necessary
Product Insert (PDF, 116K)
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Cancer Immunotherapy: Dendritic Cell Isolation/Expansion
Expand your dendritic cell (DC) cultures with our CellXVivo™ Human Monocyte-derived DC Differentiation Kit with an optimized protocol and optimized reagents. Or you can use our specially-designed StemXVivo® Serum-Free Dendritic Cell Base Media supplemented with our high-quality recombinant Cytokines and Growth Factors. For DC vaccine preparation with more rigorous documentation, take advantage... More Info
Multiple Sclerosis: Immune Cell Access to the Central Nervous System
First Published in R&D Systems' 2006 Catalog
Ig Superfamily Cell Adhesion Molecules
Multiple sclerosis... More Info
Immune Checkpoint Blockade: Blocking Antibodies
Blockade of immune checkpoint molecules, such as CTLA-4 and PD-1/PD-L1, is a promising therapeutic approach for cancer treatment. Unfortunately, blocking CTLA-4 or PD-1/PD-L1 is not universally successful across different cancer types and patients. It is thought that co-targeting multiple checkpoint molecules simultaneously could improve the effectiveness of this strategy. Take... More Info
Citations: Chemokine-related Cancer Research
Weiss, J. et al. (2009) Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment. Proc. Natl. Acad. Sci. USA 106:19455.
Mouse CCL17/TARC Quantikine® ELISA Kit (Catalog # MCC170) Mouse CCL22/MDC Quantikine ELISA Kit (Catalog # MCC220) Sample: Mouse tumor homogenate Application: ELISA
Horst, D. et al. (2009)... More Info