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Non-Traditional Notch Activation Promotes the Cancer Stem Cell Phenotype

Article

Introduction to Cancer Stem Cells Cancer stem cells (CSCs) are classically described as a tumor cell subpopulation that is multipotent, oncogenic, and capable of self-renewal.1,2 They may serve as an ongoing source for differentiating tumor cells and can exhibit characteristics that confer resistance to chemotherapy, including low proliferation rates and the expression of detoxifying enzymes...

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Notch Signaling

Article

Notch was first described in 1919 and has been implicated in a variety of developmental processes including somite formation, border definition, anterior and posterior identification, neurogenesis, angiogenesis, and lymphoid development.1-3 The discovery of Notch originated with the description of a mutant fly phenotype characterized by notches in fly wing margins.1 Subsequent studies revealed...

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Notch Signaling Pathways

Pathways

The Notch family of receptors includes Notch-1, -2, -3, and -4 are highly conserved proteins with a wide range of physiological roles including regulating cell fate, proliferation, angiogenesis, cell survival, and the immune response. Like many other proteins associated with these processes, aberrant Notch activity is reported to have complex and context-dependent effects on tumorigenesis. Upon...

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Assays for analytes represented in the Human Non-Hematopoeitic Array

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Analyte DuoSet® and DuoSet IC ELISA Development Systems Quantikine® ELISA...

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T Cells Made Easy: T Cells from Embryonic Stem Cells

Article

Lymphoid progenitors from bone marrow enter and move through the thymus where they are exposed to an array of signals responsible for their progression through T cell lineage pathways.1,2 The potential complexity generated by the many possible combinations of signals led to the notion that simple in vitro culture systems would not be sufficient to support the intricacies of T cell development....

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Taking Advantage of Notch in Stem Cell Expansion

Article

The future utilization of stem cell therapy for neurodegenerative disease has been impeded by the limited numbers of stem cells that can be generated in vitro for transplantation, the potential immune response to the transplanted cells, and the sparse population of endogenous progenitor cells that exist in vivo. Thus, in addition to mastering the isolation and molecular guidance of stem cells,...

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Developmental Apoptosis & Satellite Glial Cell Precursors

Article

Successful developmental processes require two things: 1) proper timing, and 2) proper positioning. These two factors are, by and large, linked. For example, a decrease in responsiveness to a growth factor may extinguish a mitogenic or chemoattractive effect, while an increase in responsiveness to an environmental cue may have the opposite effect. Cell death can be considered a timing event, one...

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Human Soluble Receptor Array Kit Non-Hematopoietic Panel

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Human sReceptor Array Kit Non-Hematopoietic Panel Ordering Information Introduction R&D Systems Human Soluble Receptor Array Kit Non-Hematopoietic Panel (Catalog # ARY012) is a rapid, sensitive, and economical tool used to simultaneously detect the relative levels of 119 different soluble receptors expressed and released by non-hematopoietic cells in a single sample. No specialized...

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Intestinal Lamina Propria Cell Markers

Technical Resource

Request Mucosal Immunity of the Intestine Poster The intestinal lamina propria contains many types of myeloid and lymphoid cells that maintain tolerance or carry out inflammatory responses. Click on these tabs for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study...

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Atherosclerosis Disease Progression Cell Markers

Technical Resource

Click on the tabs below for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study of these cells and molecules. For a broader representation of atherosclerosis, please view our poster Atherosclerosis Disease Progression. Request Poster   Myeloid...

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