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A Homogeneous Multiplex Immunoassay for RTK Phosphorylation State that is Adaptable to HTS

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Jane Schmidt, Ph.D., Judy Haning, Shaya Anderson, & Richard K. Fuerstenberg INTRODUCTION Receptor Tyrosine Kinases (RTKs) are widely expressed transmembrane receptors for growth factors and other extracellular signaling molecules. Binding of a specific ligand leads to phospho-rylation at specific sites in the cytoplasmic tail that triggers further signal transduction processes. RTKs play...

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