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"Small Molecules" has 183 results in Resources.

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Small Molecules & Peptides

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Tocris Bioscience is the leading supplier of small molecules and peptides for life science research. The Tocris catalog consists of a unique collection of over 4,000 research tools, covering a wide range of research areas such as neuroscience, cancer, stem cells, epigenetics and signal transduction. Tocris is part of the life science division of Bio-Techne, which also includes the best in class...

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Interferons and Anti-Viral Small Molecules

Brochures

In this brochure you will find an overview of Bio-Techne products related to Interferons (type I, II, III), their receptors, and viral Interferons as well as small molecule inhibitors of Interferon function. Some of the topics and tools that you can expect to find inside are: Bioactive Recombinant Proteins Antibodies Immunohistochemistry and Flow Cytometry Antibodies Quantikine® and...

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Tocris Small Molecules for Apoptosis Research

Research Areas

Apoptosis is a process of programmed cell death that participates in many physiological processes such as organ development, immune cell education, and normal cell turnover. However, under some conditions, apoptosis can be detrimental. For example, apoptosis of neurons is associated with neurodegenerative diseases and apoptosis of CD4+ T cells is associated with HIV-1-related...

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Tocris Small Molecules for Stem Cell Research

Research Areas

Stem cell self-renewal and differentiation mechanisms are regulated by growth factors, transcription factors, and signal transduction pathways. These molecular mechanisms, such as Wnt and Hedgehog signaling pathways, can be modulated by naturally occurring and synthetic small molecules. For example, compounds can be targeted to a specific protein within a pathway, and the cellular response can...

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Tocris Small Molecules for Stroke Research

Research Areas

Scientists in the field of stroke research have defined multiple pathways that mediate stroke-induced cell death. Experimentally, the mechanisms underlying neuronal death are often elucidated through the use of small molecule agonists and inhibitors. For example, small molecules may reveal whether cell death is mediated by caspase-dependent apoptosis or through a caspase-independent pathway such...

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Parameter Kits: A New Line of Small Molecule Assays

Article

The same quality and performance researchers have come to expect using our Quantikine® line of ELISA Kits has now been applied to R&D Systems Parameter Kits. Parameter Kits are complete microplate-based assays designed to accurately measure the levels of small molecules. Kits include complete, easy to follow protocols including sample preparation methods and typical sample values. For more...

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Phospholipases, Small GTPases, and Other Molecules in the Akt Pathway

Research Areas

Phospholipases, such as phospholipase C (PLC), hydrolyze phosphatidylinositol (4,5)-bisphosphate (PIP2) to form diacylglycerol (DAG) and inositol (1,4,5)-trisphosphate (IP3), both of which are second messenger signaling molecules. The Ras superfamily of small GTPases are signaling proteins that are active when GTP-bound and inactive following hydrolysis of the bound GTP to GDP. The...

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Suppression of Microglia-Mediated Neuroninflammation by Small Molecule NF-kB Inhibitors

Scientific Abstract Posters

Brian Astry, Rainer Grant, Katherine Bradley, Kathryn Brumbaugh, Jim Rivard, Makenna Carlson-Habegger, Andrew Hudacek, and Greta Wegner ABSTRACT It has been shown that long-term production of proinflammatory cytokines by activated microglia plays a role in neurodegenerative disorders like Parkinson’s disease and multiple sclerosis. Here we investigated if inhibition of theNF-κB signaling...

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Tocris Small Molecules for Cytoskeleton and Motor Proteins Research

Research Areas

Microfilaments, intermediate filaments and microtubules are three types of filaments that form the cytoskeleton. These filaments contribute to cell motility, cytokinesis, cell shape, and the movement of cargo and organelles within cells. While intermediate filaments primarily serve a structural role in the cell, both microfilaments and microtubules are involved in active processes which are...

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Tocris Small Molecules for Oxidative Stress and Nitric Oxide Research

Research Areas

At low levels, reactive oxygen species (ROS) and reactive nitrogen species (RNS) exert important physiological actions. For example, ROS and RNS are generated by macrophages and neutrophils in response to infectious agents, they act as second messengers to regulate vascular tone, and they can promote cell survival and proliferation. However, in excess, ROS and RNS are capable of damaging...

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