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"VEGF R2" has 39 results in Resources.

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VEGF - VEGF R2 Signaling Pathways

Pathways

Members of the vascular endothelial growth factor (VEGF) family are master regulators of physiological and pathological vasculogenesis, angiogenesis, and lymphangiogenesis. The VEGF family consists of six members VEGF-A (VEGF), VEGF-B, VEGF-C, VEGF-D, viral VEGF-E, and placental growth factor (PlGF). Human VEGF is composed of eight exons and can exist as multiple alternatively spliced isoforms...

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VEGF Family

Research Areas

View VEGF-VEGF R2 Signaling Pathways Vascular Endothelial Growth Factor (VEGF) family members are potent mitogenic and angiogenic proteins with critical physiological roles in development and wound healing. In addition, they are also centrally involved in promoting tumor growth and vascular disease. Members of the VEGF gene family include VEGF/VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E,...

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VEGF Family Ligands

Research Areas

Mammalian members of the VEGF family include VEGF (VEGF-A), -B, -C, -D, and the closely related PlGF (placenta growth factor). They are disulfide-linked dimeric proteins that are best known as regulators of physiological and pathological vasculogenesis, angiogenesis, and lymphangiogenesis. Receptors for VEGF family ligands include the tyrosine kinases VEGF R1 (Flt-1), VEGF R2 (KDR or Flk-1), VEGF...

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Regulation of VE-Cadherin and VEGF R2 by VEGF

Article

VE-Cadherin and VEGF R2 are transmembrane glycoproteins that are expressed in the adherens junctions between vascular endothelial cells (EC). VE-Cadherin interacts homophilically between neighboring cells to provide strength to the endothelium. VE-Cadherin adhesion is reduced during angiogenesis and leukocyte extravasation, two processes that require decreased EC attachment. It is well...

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Soluble VEGF R2: Controlling Lymphangiogenesis

Article

Under normal physiological conditions, angiogenesis (blood vessel formation) and lymphangiogenesis (lymphatic vessel formation) are tightly regulated processes that occur exclusively during embryonic development, pregnancy, and wound healing. Vascular endothelial growth factor (VEGF) and VEGF receptors are key mediators of this regulation. VEGF-A,-B,-C, and -D, and VEGF receptors 1, 2, and 3...

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VEGF Receptors and Regulators on Endothelial Cells

Research Areas

Atherosclerosis DiseaseProgression Poster VEGF R1, R2, R3 and Neuropilin-1 and -2 are expressed on vascular endothelial cells where they play critical roles in angiogenesis and vessel branching during embryonic development, the female reproductive cycle, and wound healing. These receptors are required for regulating endothelial cell proliferation, migration, and survival. In disease, they are...

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VEGF R3 Marks a New Class of Endothelial Stem Cell

Article

VEGF family members (VEGF, VEGF-B, VEGF-C, and VEGF-D) are intimately involved in vascular and lymphatic development, growth, and function. These four factors signal through three receptor tyrosine kinases, VEGF R1 (Flt-1), VEGF R2 (Flk-1, KDR), and VEGF R3 (Flt-4), to affect gene expression. While VEGF R2 had been implicated previously as the VEGF receptor involved in embryonic as well as in...

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Non-Human Primate Cross-Reactivity Results - ICAM-3 to VEGF R2

Technical Resource

Due to the high degree of sequence similarity between human and non-human primate protein sequences, our anti-human antibodies have often been used in non-human primate samples. Below is a list of selected references for a variety of antibodies demonstrating their value in non-human primate research. References have not been judged for inclusion or exclusion based on scientific merit.ACE to...

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Vasohibin: A negative regulator of angiogenesis

Article

Angiogenic factors, typified by VEGF and FGF basic (also known as FGF2), promote vascular endothelial cell (EC) proliferation and organization into vascular tubule networks, while angiogenesis inhibitors restrain the process. A novel EC-derived protein, vasohibin, has recently been described that operates in a direct negative feedback loop to limit VEGF and FGF basic-induced angiogenesis (Figure...

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Vascular Endothelial Growth Factor (VEGF)

Article

First printed in R&D Systems' 2000 Catalog. Introduction Angiogenesis is a process of new blood vessel development from pre-existing vasculature. It plays an essential role in embryonic development, normal growth of tissues, wound healing, the female reproductive cycle (i.e., ovulation, menstruation and placental development), as well as a major role in many diseases.1 Particular interest has...

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