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Cancer Immunotherapy: Cancer Vaccines

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Cancer vaccines are typically prepared with antigen presenting cells such as plasmacytoid or myeloid dendritic cells (DC). Tumor associated antigens (TAA) can be derived from whole tumor cells, tumor cell lysates, or synthetic peptides from tumor lysates. DC are pulsed with the TAA which are presented on the DC surface in complex with MHC molecules. Alternatively, DC can be transduced with a...

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Cancer Biomarkers

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Cancer Immunotherapy Research Products Tumor markers are endogenous proteins or metabolites whose amounts or modifications are indicative of tumor state, progression characteristics, and response to therapies. They are present in tumor tissues or body fluids and encompass a wide variety of molecules, including transcription factors, cell surface receptors, and secreted proteins. Effective tumor...

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Hematologic Cancers

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Cancer Immunotherapy Research Products Hematologic malignancies (leukemia, lymphoma, and myeloma) are cancers of the blood that arise in the bone marrow or lymphatic system. Generally, these cancers can be characterized by unregulated proliferation and impaired differentiation of transformed myeloid or lymphoid cells. Many blood cancers have been treated by high-dose, non-specific...

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Cancer Immunotherapy Research

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This brochure provides a brief description of tools that are useful for assaying the activation, expansion, characterization and isolation of T cells. This brochure also provides tools for examining the immunosuppressive tumor microenvironment as well as the immune check point and T cell exhaustion. They include: Antibodies for T Cell activation, T Cell exhaustion and immune checkpoint...

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Cancer Immunotherapy Strategies

Posters

Cancer immunotherapy is showing huge promise as a cancer treatment strategy. This approach aims to utilize the patient’s own immune system to target and kill the cancer cells. One barrier to successful cancer immunotherapy is the tumor microenvironment, which recruits immunosuppressive cells that can inhibit endogenous anti-tumor responses. Request Poster  

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Cancer Immunotherapy: Antigen Presentation

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Tumor-associated antigens (TAA) can be internalized by receptors on antigen presenting cells such as dendritic cells (DC). They are processed into short peptides by a variety of proteases and then loaded onto MHC molecules for expression on the cell surface. Classically, the presentation of extracellular-derived antigens involves MHC class II molecules and promotes CD4+ helper T cell activation...

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Cancer Immunotherapy: Tumor Microenvironment

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A large body of evidence suggests that tumors create an immunosuppressive microenvironment that inhibits the immune system’s natural ability to recognize and destroy tumor cells. This is accomplished via several mechanisms, including the recruitment of immunosuppressive cells, activation of immune checkpoint pathways, and exclusion of T cells. Gaining a better understanding of...

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Cancer Immunotherapy: Vaccine Monitoring

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Make sure your vaccine is inducing an inflammatory immune response. If you’re using a DNA vector-based vaccine, you can monitor protein expression from the vector with antibodies from our vast selection.   IFN-gamma IL-12 IL-2 IL-15   IL-15/IL-15 R alpha Complex Proteome Profiler Antibody Arrays   Luminex Assays and High Performance...

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Cancer Stem Cell Markers

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As for all stem cells, oncogenically transformed cancer stem cells (CSCs) are defined by their ability for self-renewal and multipotency. The CSC hypothesis states that, although CSCs represent a rare population of cells within a tumor, their high tumorigenic capacity drives tumorigenesis. Due to their intrinsic stem cell-like properties, CSC proliferation generates more CSCs, and all the...

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Cancer Stem Cells

Brochures

This brochure walks through tools for isolating, culturing, and characterizing cancer stem cells. Some of the topics and tools that you can expect to find inside are: Cell Selection Kits for cancer stem cell research Media for tumorsphere growth Antibodies for tissue-specific cancer stem cells Small molecules Epithelial to Mesenchymal Transition (EMT) inducing media and...

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