Fibroblast Growth Factor 9 (FGF-9)
First printed in R&D Systems' 1996 Catalog.
Consistent with their names, most FGFs initiate fibroblast proliferation. This has been demonstrated for FGFs 1 - 6, plus 8 and 9.1-8 However, the general FGF designation is clearly limiting by its description of one target cell and one biological activity. For instance the original FGF molecule (now known as FGF-2 or FGF basic) also induces... More Info
Recombinant Proteins for Organoid Culture
Optimizing Organoid Culture Conditions
Identifying and optimizing the conditions for culturing organoids can be technically challenging. Organoid cultures typically contain multiple components and can be highly variable for different types of organoids. As a result, it can take time, and a lot of trial and error to find the appropriate conditions to support robust organoid... More Info
FGF Family Signaling Pathways
The mammalian Fibroblast Growth Factor (FGF) superfamily consists of eighteen secreted proteins (FGF-1 – FGF-10 and FGF-16 – FGF-23) and four intracellular FGFs (FGF-11 – FGF-14), known as FGF homologous factors. The secreted FGFs belong to one of six subfamilies (FGF-1, FGF-4, FGF-7, FGF-8, FGF-9, and FGF-19) based on sequence homology, biological functions, and evolutionary... More Info
Fibroblast Growth Factors (FGFs)
First printed in R&D Systems' 2001 Catalog.
Human FGF Structural Information
The name "fibroblast growth factor" (FGF) is a limiting description... More Info
Fibroblast Growth Factors and their Receptors
There are nine identified members of the fibroblast growth factor (FGF) family and four high-affinity receptors, two with splice variant isoforms.1,2 The FGFs play major roles in development, wound healing, hematopoiesis, and tumorigenesis.1,3,5 The name FGF is misleading.3 While some FGFs do, indeed, initiate fibroblast proliferation, they induce proliferation of many other cells as well4, and... More Info
Organoid and 3D Culture Reagents
Organoid and three-dimensional (3-D) cell culture are emerging as pivotal systems for understanding human organ development, modeling disease, screening for drug efficacy or toxicity, and investigating personalized medicine. The reagents and protocols needed to culture these advanced multi-cellular in vitro tissues vary by organ, species, and whether they are being generated from... More Info