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"gsk-3" has 19 results in Resources.

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Wnt Intracellular Signaling

Research Areas

Multiple proteins are involved in mediating Wnt signaling. The three established Wnt signaling pathways are referred to as the canonical pathway, the planar cell polarity (PCP) pathway, and the Wnt-Ca2+ pathway. Proteins that promote the canonical beta-Catenin-dependent signaling pathway include GSK-3 beta, Casein Kinase 1 (CK1), Dishevelled, beta-Catenin, and co-activators such as Bcl-9 and...

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Proteome Profiler™ MAPK Array Kit Cross-reactivity results

Technical Resource

R&D Systems Proteome Profiler™ MAPK Array Kit may be suitable for use in multiple model systems.   Human Mouse Rat ERK1 x x x ERK2 x x x JNK1 x x x JNK2 x x x JNK3 x NA NA JNK...

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Human Phospho-MAPK Array Kit

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Human Phospho-MAPK Array Kit Ordering Information Introduction The Human Phospho-Mitogen-activated Protein Kinase (MAPK) Antibody Array (Catalog # ARY002B) is an economical tool used to simultaneously detect the relative phosphorylation of 24 kinases without performing numerous immunoprecipitation and/or Western blots. Kinases are captured by 26 different antibodies spotted in duplicate on...

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Western blotting antibodies for analytes related to the Human Phospho-MAPK Array Kit

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Analyte Phospho-Specific Antibodies Affinity Purified Polyclonal Antibodies (Total) Monoclonal Antibodies (Total) Labeled Antibodies (Total) Akt1 (S473)   AF1775, AF17751 MAB1775, MAB17752   Akt2 (S474)   AF2315, AF23151 MAB2315   Akt3 (S472)     MAB1463   Akt pan (S473, S474,...

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Assays for analytes represented in the Human Phospho-MAPK Array Kit

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Analyte DuoSet® IC ELISA Development System (Total) DuoSet® IC ELISA Development Systems (Phospho) Cell-based ELISA Kits Surveyor™ IC ELISA Kits Akt1 (S473) DYC1775 DYC2289C     Akt2 (S474) DYC2315       Akt3 (S472)         Akt pan (S473, S474,...

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Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling

Pathways

Wnts are a large family of secreted glycoproteins that play a central role in embryonic development, differentiation, cell motility, cell proliferation, and adult tissue homeostasis. Wnt signaling can activate beta-Catenin-dependent TCF/LEF transcription and at least two well-characterized beta-Catenin-independent pathways, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. The...

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Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways

Pathways

Wnts are a large family of secreted glycoproteins that play a central role in embryonic development, differentiation, cell motility, cell proliferation, and adult tissue homeostasis. Wnt signaling can activate beta-Catenin-dependent TCF/LEF transcription and at least two well-characterized beta-Catenin-independent pathways, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. The...

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Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways

Pathways

Wnts are a large family of secreted glycoproteins that play a central role in embryonic development, differentiation, cell motility, cell proliferation, and adult tissue homeostasis. Wnt signaling can activate beta-Catenin-dependent TCF/LEF transcription and at least two well-characterized beta-Catenin-independent pathways, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. The...

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Neurofibrillary Tangle Formation

Research Areas

A-beta SignalingView Interactive Pathway Amyloid plaques, neurofibrillary tangles (NFTs), and neuronal loss are the major pathological hallmarks of Alzheimer’s disease (AD). NFTs are intracellular aggregates of hyperphosphorylated Tau. Tau is a highly soluble, unfolded microtubule-associated protein (MAP) that regulates microtubule dynamics and reorganization. It is abundant in the central...

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