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Innate Lymphoid Cell Differentiation Pathways

Pathways

Innate Lymphoid Cells (ILCs) are a newly-identified subset of hematopoietic effector cells. ILCs are implicated in the preservation of epithelial integrity of the gut, the lung and the skin, and also participate in immune responses against pathogens through rapid and potent cytokine production. All ILC populations develop from a common lymphoid progenitor (CLP), which is localized to the fetal...

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Immunology News: Researchers Report the Identification of a New Regulatory Innate Lymphoid Cell Subset that Suppresses Innate Intestinal Inflammation

Blog

Regulatory ILCs Suppress ILC1- and ILC3-Induced Innate Intestinal Inflammation Innate lymphoid cells (ILCs) are a recently described population of lymphocytes that play a critical role in innate immune responses and tissue remodeling. Multiple studies suggest that ILCs are particularly important for maintaining epithelial barriers and regulating immune responses at mucosal surfaces such as...

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Dendritic Cell Development

Research Areas

Dendritic cells (DCs) are a heterogeneous population of immune cells that are critical mediators of innate and adaptive immunity. DC precursors develop in the bone marrow. While plasmacytoid DCs complete development in the bone marrow, most DCs complete development in lymphoid and peripheral tissues. Knockout mouse models have identified several cytokines and transcription factors that are...

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MimEX Tissue Model Systems

Product Highlights

  The MimEX™ Tissue Model Systems product line has been discontinued. We apologize for any inconvenience this may cause to your work and research. If you have specific questions regarding this product line discontinuation, please contact techsupport@bio-techne.com   If you are interested in more 3-D culture and organoid recipes from R&D Systems, check out our organoid...

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Airway Inflammation Markers

Technical Resource

Click on these tabs for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study of these cells and molecules. For a broader representation of airway immunity, please view our poster Airway Inflammation in Asthma. Request Airway Inflammation in Asthma...

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Intestinal Lamina Propria Cell Markers

Technical Resource

Request Mucosal Immunity of the Intestine Poster The intestinal lamina propria contains many types of myeloid and lymphoid cells that maintain tolerance or carry out inflammatory responses. Click on these tabs for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study...

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ILC Poster References

Technical Resource

Review Group 1 ILCs Group 2 ILCs Group 3 ILCs Common Lymphoid progenitor Transcription factors Review Bordon, Y. (2014) Nat. Rev. Immunol. 14:133. Innate lymphoid cells: on the origin of ILCs. Colonna, M. (2013) Nature 498:42. Immunology: An innate regulatory cell. Cherrier, M. & Eberl, G. (2012) Curr. Opin. Immunol. 24: 178. The development of LTi cells. Cording, S. et...

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Organoid and 3D Culture Reagents

Product Categories

Organoid and three-dimensional (3-D) cell culture are emerging as pivotal systems for understanding human organ development, modeling disease, screening for drug efficacy or toxicity, and investigating personalized medicine. The reagents and protocols needed to culture these advanced multi-cellular in vitro tissues vary by organ, species, and whether they are being generated from...

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Atherosclerosis Disease Progression Cell Markers

Technical Resource

Click on the tabs below for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study of these cells and molecules. For a broader representation of atherosclerosis, please view our poster Atherosclerosis Disease Progression. Request Poster   Myeloid...

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