Innate Lymphoid Cell Differentiation Pathways
Innate Lymphoid Cells (ILCs) are a newly-identified subset of hematopoietic effector cells. ILCs are implicated in the preservation of epithelial integrity of the gut, the lung and the skin, and also participate in immune responses against pathogens through rapid and potent cytokine production. All ILC populations develop from a common lymphoid progenitor (CLP), which is localized to the fetal... More Info
Dendritic Cell Development
Dendritic cells (DCs) are a heterogeneous population of immune cells that are critical mediators of innate and adaptive immunity. DC precursors develop in the bone marrow. While plasmacytoid DCs complete development in the bone marrow, most DCs complete development in lymphoid and peripheral tissues. Knockout mouse models have identified several cytokines and transcription factors that are... More Info
MimEX Tissue Model Systems
The MimEX™ Tissue Model Systems product line has been discontinued. We apologize for any inconvenience this may cause to your work and research. If you have specific questions regarding this product line discontinuation, please contact firstname.lastname@example.org
If you are interested in more 3-D culture and organoid recipes from R&D Systems, check out our organoid... More Info
Airway Inflammation Markers
Click on these tabs for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study of these cells and molecules. For a broader representation of airway immunity, please view our poster Airway Inflammation in Asthma.
Request Airway Inflammation in Asthma... More Info
Intestinal Lamina Propria Cell Markers
Request Mucosal Immunity of the Intestine Poster
The intestinal lamina propria contains many types of myeloid and lymphoid cells that maintain tolerance or carry out inflammatory responses. Click on these tabs for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study... More Info
ILC Poster References
Group 1 ILCs
Group 2 ILCs
Group 3 ILCs
Common Lymphoid progenitor
Bordon, Y. (2014) Nat. Rev. Immunol. 14:133. Innate lymphoid cells: on the origin of ILCs.
Colonna, M. (2013) Nature 498:42. Immunology: An innate regulatory cell.
Cherrier, M. & Eberl, G. (2012) Curr. Opin. Immunol. 24: 178. The development of LTi cells.
Cording, S. et... More Info
Organoid and 3D Culture Reagents
Organoid and three-dimensional (3-D) cell culture are emerging as pivotal systems for understanding human organ development, modeling disease, screening for drug efficacy or toxicity, and investigating personalized medicine. The reagents and protocols needed to culture these advanced multi-cellular in vitro tissues vary by organ, species, and whether they are being generated from... More Info
Atherosclerosis Disease Progression Cell Markers
Click on the tabs below for flow cytometry phenotyping suggestions and extended lists of secreted, cell surface, and intracellular markers. Each link will direct you to our product offerings for the study of these cells and molecules. For a broader representation of atherosclerosis, please view our poster Atherosclerosis Disease Progression.
Myeloid... More Info