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"il-2" has 97 results in Resources.

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IL-2 Signaling Pathways

Pathways

Featured Literature Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions Poster View Poster Featured Products Common Cytokine Receptor gamma-Chain Family Brochure View Brochure   Overview of IL-2 Signaling Pathways Interleukin-2 (IL-2) is an O-glycosylated four...

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IL-2 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Pathways

Interleukin-2 (IL-2) is an O-glycosylated four alpha-helix bundle cytokine that is primarily produced by activated T cells, dendritic cells, and B cells. The biological activity of IL-2 is mediated by binding to a cell surface receptor complex consisting of IL-2 R alpha/CD25, IL-2/IL-15 R beta, and the common gamma-chain/IL-2 R gamma subunit. IL-2 can also bind with low affinity to IL-2 R alpha...

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VSIG IgG Superfamily Members: Data Supports Their Potential as Immunotherapeutic Drug Targets

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The B7 family and other T cell co-stimulatory/co-inhibitory molecules are widely recognized as therapeutic targets for cancer immunotherapy. Many of these are members of the large immunoglobulin superfamily. V-Set and Immunoglobulin domain containing (VSIG) proteins are members of the immunoglobulin protein superfamily and are increasingly recognized as potential immuno-oncology targets. Perhaps...

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Interleukin 15 (IL-15)

Article

First printed in R&D Systems' 1996 Catalog. Overview Interleukin 15 (IL-15) is a novel cytokine that shares many biological properties with, but lacks amino acid sequence homology to, IL-2. IL-15 was originally identified in media conditioned by a monkey kidney eipthelial cell line (CVI/EBNA) based on its mitogenic activity on the murine T cell line, CTLL-2.1 IL-15 was also independently...

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Common gamma Chain Receptor Family

Research Areas

View Common Cytokine Receptor Gamma-Chain Family Signaling Pathways The common cytokine receptor gamma-chain family consists of six members, IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. All members of this family signal through receptor complexes that contain the common cytokine receptor gamma-chain subunit. The receptors for IL-4, IL-7, IL-9, and IL-21 are heterodimeric complexes...

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Cancer Immunotherapy: Utilize B7 and Butyrophilin Family Proteins

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The B7 family and other T cell co-stimulatory/co-inhibitory molecules are widely recognized as therapeutic targets for regulating the immune response. Butyrophilins are a novel class of co-stimulatory/co-inhibitory molecules that are structurally related to the B7 family and appear to have similar immunomodulatory functions. These parallels suggest that the butyrophilins or their receptors may...

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Dual-Color FluoroSpot Kits

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Complete Listing of Dual-Color FluoroSpot Kits View Full Assay Principle R&D Systems Dual-Color FluoroSpot Kits utilize the ELISpot assay principle to simultaneously detect individual cells that secrete either one or both analytes specified in the kit. These assays are highly sensitive and can quantitate actively secreting cells even when cell frequencies fall below 1 in...

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New Data: AMIGOs as T Cell Suppressors

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AMIGO family proteins (AMIGO1, AMIGO2 and AMIGO3) are cell adhesion molecules that exhibit homophilic and heterophilic binding properties. Relatively little is known about the function of this protein family. They play roles in neuronal axon tract development and cell adhesion. The mRNA expression of human AMIGO2 is significantly upregulated in Th2 cells comparison with Th0 and Th1 cells1,...

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Common Cytokine Receptor Gamma-Chain Family Signaling Pathways

Pathways

Cytokines belonging to the common cytokine receptor gamma chain family include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Members of this family signal through receptor complexes that contain the common gamma chain subunit. This subunit associates with different cytokine-specific receptor subunits to form unique heterodimeric receptors for IL-4, IL-7, IL-9, and IL-21, or associates with both...

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New DuoSet ELISA Pricing For 2019

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Take the pain out of your immunoassay development with R&D Systems DuoSet® ELISA Development Kits. With everything you need to develop the perfect sandwich immunoassay in one kit and a range of ancillary reagents to help you get the perfect ELISA. DuoSet® ELISA Development Kits contain matched antibody pairs and the basic components required to develop an immunoassay. They offer an...

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