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GFRAL is A Novel GDF-15 Receptor with a Putative Role in Appetite Disorders

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Growth Differentiation Factor 15 (GDF-15) has long been recognized as a circulating biomarker for a range of human disorders, and elevated levels have been associated with suppression of appetite. The receptor for this effect was recently revealed in four nature.com publications to be GDNF receptor-alpha-like (GFRAL), a distant member of the GDNF R family of proteins (1-4). The full receptor...

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NCAM as a Novel GDNF Family Receptor

Article

Members of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) family include GDNF, Neurturin (NTN), Artemin (ART), and Persephin (PSP). These neurotrophic factors exhibit an array of biological activities ranging from the promotion of cell survival to the enhancement of neurite outgrowth.1,2 The GDNF family signals through a multi-molecular protein complex that includes receptors of the GFR...

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GDNF Family

Research Areas

Artemin, neurturin and persephin are members of the GDNF family of ligands that also includes glial cell-derived neurotrophic factor (GDNF). GDNF family proteins are distant members of the TGF-beta superfamily. Artemin promotes the survival and growth of various peripheral and central neurons, including sympathetic and dopaminergic neurons. Neurturin exerts a positive effect on the survival of a...

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High Profile Papers Identify GFRAL as a GDF-15 Receptor and Novel Target for Obesity and Anorexia/Cachexia

Blog

Growth Differentiation Factor 15 (GDF-15) has long been recognized as a circulating biomarker for a range of human disorders, and elevated levels have been associated with suppression of appetite. The receptor for this affect was recently revealed in several publications to be GDNF receptor-alpha-like (GFRAL), a distant member of the GDNF R family of proteins (1-4). The full receptor complex is...

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Differential Interaction Between GDNF Receptor-alpha-like (GFRAL) Protein and GDNF Family Ligands on Binding and Neuroblastoma Cell Proliferation Assays

Scientific Abstract Posters

G. Wang, L. Xiong, T. Gerassenkov, V. Kalabokis, A. Person ABSTRACT The glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) is one of three neurotrophic factor families found in the nervous system. The GFLs, along with their receptors, play important roles in axon guidance, synapse formation, neuronal survival, neural regeneration, and are implicated in a number of...

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Phospho-RTK Array Coordinates

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Coordinate Receptor Family RTK/Control   Coordinate Receptor Family RTK/Control A1, A2 control PY-Control*   D1, D2 TIE Tie-2 A23, A24 control PY-Control*   D3, D3 NGFR TrkA B1, B2 EGFR EGF R   D5, D6 NGFR TrkB B3, B4 EGFR ErbB-2   D7,...

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Assays for analytes represented in the Human Phospho-Receptor Tyrosine Kinase Array Kit

Technical Resource

Analyte Quantikine® ELISA Kits DuoSet® ELISA Development System DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA Development Systems (Phospho) Cell-based ELISA...

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Bio-Techne is Helping Scientists Discover Answers about SARS-CoV-2 and COVID-19

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In late December 2019, a new virulent virus emerged in the Wuhan, Hubei province, China that produced a potentially fatal atypical pneumonia, eventually called COVID-19. It was the third time in the last two decades that an outbreak of a highly infectious agent presented a global threat. Identification and sequencing of the virus responsible for this outbreak determined that it was...

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Organoid and 3D Culture Reagents

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Organoid and three-dimensional (3-D) cell culture are emerging as pivotal systems for understanding human organ development, modeling disease, screening for drug efficacy or toxicity, and investigating personalized medicine. The reagents and protocols needed to culture these advanced multi-cellular in vitro tissues vary by organ, species, and whether they are being generated from...

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