Catalog Number: 1362
Alternate Names: Iodoresiniferatoxin, 5'-IRTX
Chemical Name: 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzeneacetate)
Biological Activity
Potent and silent vanilloid receptor antagonist, 40-fold more potent than capsazepine (Cat. No. 0464). Binds to TRPV1 (VR1) receptors expressed in HEK293 cells with a Ki of 5.8 nM.
Technical Data
  • M.Wt:
    754.6
  • Formula:
    C37H39IO9
  • Solubility:
    Soluble in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    535974-91-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro.
    Marinelli et al.
    J.Physiol., 2002;543:531
  2. Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist.
    Wahl et al.
    Mol.Pharmacol., 2001;59:9
  3. Properties of iodo-resiniferatoxin - a high affinity VR1 vanilloid receptor antagonist.
    Seabrook et al.
    Soc.Neurosci.Abstr., 2001;:925.9
Citations:

The citations listed below are publications that use Tocris products. Selected citations for 5'-Iodoresiniferatoxin include:

9 Citations: Showing 1 - 9
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  1. High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets.
    Authors: Woolcott Et al.
    J Neurosci Res 2015;10:e0123558
  2. 5-Aminosalicylic Acid Inhibits Acute Clostridium difficile Toxin A-Induced Colitis in Rats.
    Authors: Vigna
    PLoS One 2014;2014:389621
  3. Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouse.
    Authors: Gao Et al.
    Pain 2012;61:1381
  4. Plasticity of cytochrome P450 isozyme expression in rat trigeminal ganglia neurons during inflammation.
    Authors: Ruparel Et al.
    J Neurosci 2012;153:2031
  5. Functional plasticity of central TRPV1 receptors in brainstem dorsal vagal complex circuits of streptozotocin-treated hyperglycemic mice.
    Authors: Zsombok Et al.
    PLoS One 2011;31:14024
  6. Increases in transient receptor potential vanilloid-1 mRNA and protein in primary afferent neurons stimulated by protein kinase C and their possible role in neurogenic inflammation.
    Authors: Xu Et al.
    Int J Inflam 2009;87:482
  7. Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus.
    Authors: Derbenev Et al.
    J Neurosci 2006;26:9666
  8. AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties.
    Authors: Gavva Et al.
    J Pharmacol Exp Ther 2005;313:474
  9. Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
    Authors: Price Et al.
    Br J Pharmacol 2004;142:257

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