Catalog Number: 1556
Alternate Names: 6'-IRTX
Chemical Name: [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]-4-hydroxy-2-iodo-5-methoxy-benzeneacetic acid methyl ester
Biological Activity
High affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1). Displays partial agonism at human VR1 and full agonism at rat VR1.
Technical Data
  • M.Wt:
    754.6
  • Formula:
    C37H39IO9
  • Solubility:
    Soluble in ethanol and in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    335151-55-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor.
    McDonnell et al.
    Bioorg.Med.Chem.Lett., 2002;12:1189

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