High affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki
= 0.71 nM; EC50
= 130 nM at human VR1). Displays partial agonism at human VR1 and full agonism at rat VR1.
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Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor.
McDonnell et al.