6'-GNTI dihydrochloride

Catalog # Availability Size / Price Qty
6'-GNTI dihydrochloride | Kappa Opioid Receptor Agonists
1 Image
Description: Selective κ/δ opioid heterodimer receptor agonist
Alternative Names: 6'-Guanidinonaltrindole dihydrochloride

Chemical Name: 6''-Guanidinyl-17-(cyclopropylmethyl)-6,7-dehydro-4,5a-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan dihydrochloride

Purity: ≥97%

Product Details
Supplemental Products
Reviews (1)

Biological Activity

6'-GNTI dihydrochloride is a selective κ/δ-opioid heterodimer receptor agonist (EC50 = 39.8, 112.5 and > 1000 nM for κ/δ, κ/μ and δ/μ respectively) that has no effect on opioid receptor homodimers (EC50 > 1000 nM). Displays tissue-specific analgesic effects in vitro.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Transformation of a κ-opoid receptor antagonist to a κ-agonist by transfer of a guanidinium group from the 5' to 6' position of naltrindole.
    Sharma et al.
    J.Med.Chem., 2001;44:2073
  2. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.
    Waldhoer et al.
    Proc.Natl.Acad.Sci.USA, 2005;102:9050
  3. Heterodimers of G protein-coupled receptors as novel and distinct drug targets.
    Rozenfeld et al.
    Drug Discov.Today Ther.Strateg., 2006;3:437
  4. 6'-guanidinonaltrindole (6'-GNTI) is a G protein-biased κ-opioid receptor agonist that inhibits arrestin recruitment.
    Rives et al.
    J.Biol.Chem., 2012;287:27050

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for 6'-GNTI dihydrochloride

Average Rating: 5 (Based on 1 Review)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used 6'-GNTI dihydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Good product.
By Anonymous on 01/14/2020
Application: Species: Human

Successfully induced ERK1/2 phosphorylation in CHO cells expressing KOR. It’s a very reliable compound.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.