Chemical Name: 8-Methoxy-2-propionamidotetralin
Biological ActivityMelatonin receptor agonist, 20-fold selective for the MT2 (vs MT1) subtype. At human recombinant MT1 and MT2 receptors, displays pKi values of 8.23 and 8.95 respectively.
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Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors.
Browning et al.
Melatonin receptors: are there multiple subtypes?
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor.
Dubocovich et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;355:365
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