Catalog Number: 3124
Biological Activity
Selective antagonist of neuromuscular nicotinic receptors α1β1γδ. Displays selectivity for α/δ sites over α/γ sites in Torpedo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: X = Hyp, Cys-18 = C-terminal amide, Disulfide bridge between 4 - 10, 5 - 17)

  • Solubility:
    Soluble to 2 mg/ml in 10% acetonitrile
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from University of Utah
Background References
  1. α-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity.
    Martinez et al.
    Biochemistry, 1995;34:14519
  2. Solution conformation of α-Conotoxin EI, a neuromuscular toxin specific for the α1/δ subunit interface of Torpedo nicotinic acetylcholine receptor.
    Park et al.
    J.Biol.Chem., 2001;276:49028
  3. Novel α-conotoxins from Conus spurius and the α-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors.
    Lopez-Vera et al.
    FEBS Lett., 2007;274:3972
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