Nicotinic receptor antagonist that displays selectivity for homomeric α
7 and α
9 receptors (IC50
values are 220 and 1800 nM respectively). Displays no effect on α
3 and α
4 subunit combinations.
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All Tocris products are intended for laboratory research use only.
Sold under license from University of Utah
A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI.
McIntosh et al.
α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors.
Johnson et al.
α-Conotoxin-ImI: a competitive antagonist at α-Bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons.
Pereira et al.