Catalog Number: 3119
Biological Activity
Nicotinic receptor antagonist that displays selectivity for homomeric α7 and α9 receptors (IC50 values are 220 and 1800 nM respectively). Displays no effect on α2β2, α3β2, α4β2, α2β4, α3β3 and α4β4 subunit combinations.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Cys-12 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 12)

  • Solubility:
    Soluble to 1 mg/ml in 20% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from University of Utah
Background References
  1. A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI.
    McIntosh et al.
    J.Biol.Chem., 1994;269:16733
  2. α-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric α7 and α9 receptors.
    Johnson et al.
    Mol.Pharmacol., 1995;48:194
  3. α-Conotoxin-ImI: a competitive antagonist at α-Bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons.
    Pereira et al.
    J.Pharmacol.Exp.Ther., 1996;278:1472
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