TRPV1 antagonist (IC50
= 1.4 μ
M). Reduces capsaicin-mediated Ca2+
influx in vitro
; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Brain penetrant and orally bioavailable.
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All Tocris products are intended for laboratory research use only.
Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties.
Trevisan et al.