ACV 1

Catalog # Availability Size / Price Qty
3205/100U
Cat.No. 3205 - ACV 1 | Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Asn-Tyr-Asp-His-Pro-Glu-Ile-Cys-NH2 | CAS No. 740980-24-9
1 Image
Description: α9α10-selective antagonist
Alternative Names: Conotoxin Vc1.1
Product Details
Citations (1)
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Biological Activity

Neuronal nicotinic receptor antagonist that displays selectivity for the α9α10 subtype (IC50 values are 19, 140, 980, 4200 and 7300 nM for α9α10, α6/α3β2β3, α6/α3β4, α3β4 and α3β2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons.

Technical Data

M.Wt:
1806.98
Formula:
C71H103N23O25S4
Sequence:
GCCSDPRCNYDHPEIC

(Modifications: Cys-16 - C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)

Storage:
Store at -20°C
CAS No:
740980-24-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold under license from Dr Bruce Livett

Background References

  1. A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo.
    Sandall et al.
    Biochemistry, 2003;42:6904
  2. Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins?
    Nevin et al.
    Mol.Pharmacol, 2007;72:1406
  3. Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor
    Halai et al.
    J.Biol.Chem., 2009;284:20275
  4. Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors.
    Vincler et al.
    Proc.Nat.Acad.Sci.USA, 2006;103:17880

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Citation for ACV 1

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