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3205 has been discontinued.
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Additional Nicotinic Receptor Antagonists Peptide
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Description: α9α10-selective antagonist
Alternative Names: Conotoxin Vc1.1
Product Details
Citations (1)

Biological Activity

Neuronal nicotinic receptor antagonist that displays selectivity for the α9α10 subtype (IC50 values are 19, 140, 980, 4200 and 7300 nM for α9α10, α6/α3β2β3, α6/α3β4, α3β4 and α3β2 subtypes respectively). Alleviates neuropathic pain in three rat models of human neuropathic pain and accelerates functional recovery of injured neurons.

Technical Data


(Modifications: Cys-16 - C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16)

Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dr Bruce Livett

Background References

  1. A novel α-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo.
    Sandall et al.
    Biochemistry, 2003;42:6904
  2. Are α9α10 nicotinic acetylcholine receptors a pain target for α-conotoxins?
    Nevin et al.
    Mol.Pharmacol, 2007;72:1406
  3. Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor
    Halai et al.
    J.Biol.Chem., 2009;284:20275
  4. Molecular mechanism for analgesia involving specific antagonism of α9α10 nicotinic acetylcholine receptors.
    Vincler et al.
    Proc.Nat.Acad.Sci.USA, 2006;103:17880

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for ACV 1

The citations listed below are publications that use Tocris products. Selected citations for ACV 1 include:

1 Citation: Showing 1 - 1


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