Catalog Number: 3716
Alternate Names: NSC 680410
Chemical Name: 4-[[(2,5-Dihydroxyphenyl)methyl]amino]benzoic acid tricyclo[3.3.1.13,7]dec-1-yl ester
Biological Activity
p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro. Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro.
Technical Data
  • M.Wt:
    393.48
  • Formula:
    C24H27NO4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    241127-58-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of the bcl/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro.
    Svingen et al.
    Clin.Cancer Res., 2000;6:237
  2. In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines.
    Avramis et al.
    Cancer Chemother.Pharmacol., 2002;50:479
  3. Effects of bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro.
    Mow et al.
    Blood, 2002;99:664
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Adaphostin include:

1 Citations: Showing 1 - 1

  1. EZH2 silencing with RNA interference induces G2/M arrest in human lung cancer cells in vitro.
    Authors: Xia Et al.
    Biomed Res Int 2014;2014:348728

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