tyrosine kinase inhibitor (IC50
= 14 μ
M). Induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50
values range from 16.8 to 216.3 nM) in vitro
. Displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Effects of the bcl/abl kinase inhibitors AG957 and NSC 680410 on chronic myelogenous leukemia cells in vitro.
Svingen et al.
Clin.Cancer Res., 2000;6:237
In vitro and in vivo evaluations of the tyrosine kinase inhibitor NSC 680410 against human leukemia and glioblastoma cell lines.
Avramis et al.
Cancer Chemother.Pharmacol., 2002;50:479
Effects of bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro.
Mow et al.
The citations listed below are publications that use Tocris products. Selected citations for Adaphostin include:
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