Ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses the doxorubicin-resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor.
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IFN-beta regulates CD73 and adenosine expression at the blood-brain barrier.
Niemelä et al.
Purinergic control of vascular tone in the retina.
Kur et al.
Evidence for the involvement of ecto-5'-nucleotidase (CD73) in drug resistance.
Ujházy et al.
The citations listed below are publications that use Tocris products. Selected citations for Adenosine 5'-(α,β-methylene)diphosphate sodium salt include:
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