Biological ActivityKV4 channel blocker. Blocks A-type K+ current (ISA) in mouse cerebellar granule neurons. The accessory dipeptidyl peptidase-like proteins (DPP) 6 and 10 are required for blockade.
(Modifications: X = Glp, Disulfide bridge: 8-28,13-33,17-35)
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Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels.
Maffie et al.
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AmmTX3 was used on Kv7.1 channels to assess its blocking action with increasing temperature.