Peptide found in plaques in the brains of patients with Alzheimer's disease. Shown to have both neurotrophic and neurotoxic effects.
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Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield.
Miguel-Hidalgo and Cacabelos
Acta Neuropathol., 1998;95:455
Beta-amyloid(1-40) effects on behavior and memory.
Cleary et al.
Brain Res., 1995;682:69
β-Amyloid protein induces platelet aggregation and supports platelet adhesion.
Kowalska and Badellino
Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides.
Yankner et al.