Catalog Number: 1428
Biological Activity
Human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

Control Peptide also available.

Technical Data
  • M.Wt:
    4514.08
  • Formula:
    C203H311N55O60S
  • Sequence:
    DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  • Solubility:
    Soluble to 1 mg/ml in 50mM Tris buffer
  • Storage:
    Desiccate at -20°C
  • CAS No:
    107761-42-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders.
    Van Nostrand et al.
    Ann.N.Y.Acad.Sci., 1996;777:297
  2. Amyloid beta peptide of Alzheimer's disease downregulates bcl-2 and upregulates bax expression in human neurons.
    Paradis et al.
    J.Neurosci., 1996;16:7533
  3. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
    Glenner and Wong
    Biochem.Biophys.Res.Commun., 1984;120:885
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Amyloid β-Peptide (1-42) (human) include:

4 Citations: Showing 1 - 4
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  1. Non-Neuronal Cells Are Required to Mediate the Effects of Neuroinflammation: Results from a Neuron-Enriched Culture System.
    Authors: Hui Et al.
    PLoS One 2016;11:e0147134
  2. Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology.
    Authors: Pourbadie Et al.
    J Neuroinflammation 2015;10:e0117555
  3. β-amyloid induces a dying-back process and remote trans-synaptic alterations in a microfluidic-based reconstructed neuronal network.
    Authors: Deléglise Et al.
    Acta Neuropathol Commun 2014;2:145
  4. Palmitoylethanolamide exerts neuroprotective effects in mixed neuroglial cultures and organotypic hippocampal slices via peroxisome proliferator-activated receptor-α.
    Authors: Scuderi Et al.
    Dent Res J (Isfahan) 2012;9:49
Tocris Peptides
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Amyloid β-peptide (42-1) (human)

3391 1  
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