-peptide fragment; minimum section required to bind to brain proteins. Binds with high affinity to α
7-nicotinic ACh receptors, and impairs memory retention following central administration in mice in vivo
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An amyloid β-protein fragment, A b[12-28], equipotent impairs post-training memory processing when injected into different limbic system structures.
Flood et al.
Brain Res., 1994;663:271
Nicotine enhances the depressive actions of A β 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo.
Freir and Herron
Binding of amyloid b-protein to intracellular brain proteins in rat and human.
Ray et al.