Amyloid β-peptide (1-40) (rat)

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2424/1
Amyloid β-peptide (1-40) (rat)
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Description: Amyloid β-protein fragment
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Biological Activity

Rat form of the amyloid β-peptide found in plaques associated with Alzheimer's disease. Shown to have both neurotrophic and neurotoxic effects.

Technical Data

M.Wt:
4233.76
Formula:
C190H291N51O57S
Sequence:
DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVV
Solubility:
Soluble to 1 mg/ml in 1% Ammonia
Storage:
Desiccate at -20°C
CAS No:
144409-98-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
    Yankner et al.
    Science, 1990;250:279
  2. Beta-amyloid(1-40) effects on behavior and memory.
    Cleary et al.
    Brain Res., 1995;682:69
  3. Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield.
    Miguel-Hidalgo and Cacabelos
    Acta Neuropathol., 1998;95:455
  4. β-Amyloid protein induces platelet aggregation and supports platelet adhesion.
    Kowalska and Badellino
    Biochem.Biophys.Res.Comm., 1994;205:1829

Product Datasheets

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