Amyloid β-peptide (1-42) (rat)

Catalog # Availability Size / Price Qty
2425/500U
Amyloid β-peptide (1-42) (rat)
1 Image
Description: Predominant amyloid β-protein fragment
Product Details
Citations (1)
Reviews

Biological Activity

Rat form of the predominant amyloid β-peptide found in plaques associated with Alzheimer's disease. Leads to a large shift in the bax/bcl-2 ratio in favour of pro-apoptotic bax. Neurotoxic.

Technical Data

M.Wt:
4417.99
Formula:
C199H307N53O59S
Sequence:
DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Solubility:
Soluble to 1 mg/ml in 0.1% Ammonia
Storage:
Desiccate at -20°C
CAS No:
166090-74-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders.
    Van Nostrand et al.
    Ann.N.Y.Acad.Sci., 1996;777:297
  2. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
    Glenner and Wong
    Biochem.Biophys.Res.Comm., 1984;120:885
  3. Alzheimer's amyloid β-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: An intriguing role for methionine 35.
    Clementi et al.
    Biochem.Biophys.Res.Comm., 2006;342:206

Product Datasheets

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Citation for Amyloid β-peptide (1-42) (rat)

The citations listed below are publications that use Tocris products. Selected citations for Amyloid β-peptide (1-42) (rat) include:

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