Biological ActivityRat form of the predominant amyloid β-peptide found in plaques associated with Alzheimer's disease. Leads to a large shift in the bax/bcl-2 ratio in favour of pro-apoptotic bax. Neurotoxic.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders.
Van Nostrand et al.
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
Glenner and Wong
Alzheimer's amyloid β-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: An intriguing role for methionine 35.
Clementi et al.
Citation for Amyloid β-peptide (1-42) (rat)
The citations listed below are publications that use Tocris products. Selected citations for Amyloid β-peptide (1-42) (rat) include:
1 Citation: Showing 1 - 1
Partial Amelioration of Synaptic and Cognitive Deficits by Inhibiting Cofilin Dephosphorylation in an Animal Model of Alzheimer's Disease
Authors: Yulei Et al.
Journal of Alzheimer's Disease 2016;53:1419
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