Amyloid β-Peptide (12-28) (human)
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Description: Amyloid β-peptide; minimum required for binding to brain proteins
Biological Activity
Amyloid β-peptide fragment; minimum section required to bind to brain proteins. Binds with high affinity to α7-nicotinic ACh receptors, and impairs memory retention following central administration in mice in vivo.Technical Data
M.Wt:
1955.2
Formula:
C89H135N25O25
Sequence:
VHHQKLVFFAEDVGSNK
Solubility:
Soluble to 0.70 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
107015-83-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
An amyloid β-protein fragment, A b[12-28], equipotent impairs post-training memory processing when injected into different limbic system structures.
Flood et al.
Brain Res., 1994;663:271 -
Nicotine enhances the depressive actions of A β 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo.
Freir and Herron
J.Neurophysiol., 2003;89:2917 -
Binding of amyloid b-protein to intracellular brain proteins in rat and human.
Ray et al.
Neurochem.Res., 1998;23:1277
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