Catalog Number: 4574
Chemical Name: 4-[[4-(4-Hydroxyphenyl)-1-phthalazinyl]amino]-N-phenylbenzamide
Biological Activity
FAAH-like anandamide transporter (FLAT) inhibitor (IC50 = 1.8 μM); cytosolic variant of FAAH-1 that binds anandamide. Attenuates anandamide internalization and deactivation in vitro and in vivo respectively. Exhibits analgesic effects in rodent models of CB1-mediated nociceptive and inflammatory pain.
Technical Data
  • M.Wt:
    432.47
  • Formula:
    C27H20N4O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    488793-85-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A catalytically silent FAAH-1 variant drives anandamide transport in neurons.
    Fu et al.
    Nat.Neurosci., 2011;15:64
  2. "Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control.
    Piscitelli and Marzo
    ACS Chem.Neurosci., 2012;3:356

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