AZ 10417808

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AZ 10417808 | CAS No. 331645-84-2 | Caspase Inhibitors
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Description: Selective non-peptide caspase-3 inhibitor
Alternative Names: AQZ-1

Chemical Name: 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 μM). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50 = 14.9 μM).

Technical Data

M.Wt:
434.23
Formula:
C18H13Cl2N5O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
331645-84-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Background References

  1. Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis.
    Scott et al.
    J.Pharmacol.Exp.Ther., 2003;304:433

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Citation for AZ 10417808

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