Selective non-peptide inhibitor of caspase-3 (Ki
= 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki
> 10 μ
M). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50
= 14.9 μ
Soluble to 25 mM in DMSO
Store at RT
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Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis.
Scott et al.
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