Chemical Name: 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide
Biological ActivitySelective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 μM). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50 = 14.9 μM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis.
Scott et al.
Citation for AZ 10417808
The citations listed below are publications that use Tocris products. Selected citations for AZ 10417808 include:
1 Citation: Showing 1 - 1
High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses.
Authors: Cruz Et al.
PLoS Negl Trop Dis 2013;7:e2073
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