Catalog Number: 2172
Alternate Names: AQZ-1
Chemical Name: 2-[(3,4-Dichlorophenyl)amino]-1,4-dihydro-6-nitro-4-oxo-N-2-propenyl-8-quinazolinecarboxamide
Biological Activity
Selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 μM). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50 = 14.9 μM).
Technical Data
  • M.Wt:
    434.23
  • Formula:
    C18H13Cl2N5O4
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    331645-84-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Background References
  1. Novel small molecule inhibitors of caspase-3 block cellular and biochemical features of apoptosis.
    Scott et al.
    J.Pharmacol.Exp.Ther., 2003;304:433
Citations:

The citations listed below are publications that use Tocris products. Selected citations for AZ 10417808 include:

1 Citations: Showing 1 - 1

  1. High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses.
    Authors: Cruz Et al.
    PLoS Negl Trop Dis 2013;7:e2073

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