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AZ 12080282 dihydrochloride

4838 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4838/10
4838/50
AZ 12080282 dihydrochloride | Hedgehog Signaling Inhibitors
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Description: Inhibitor of Hedgehog (Hh) signaling

Chemical Name: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride

Purity: ≥98%

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Biological Activity

Inhibitor of Hedgehog (Hh) signaling (IC50 <0.012 μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable.

Technical Data

M.Wt:
457.35
Formula:
C23H20N4O2.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Product Datasheets

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