AZ 12080282 dihydrochloride
Chemical Name: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride
Purity: ≥98%
Biological Activity
Inhibitor of Hedgehog (Hh) signaling (IC50 <0.012 μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Discovery of novel hedgehog antagonists from cell-based screening: isoteric modification of p38 bisamides as potent inhibitors of SMO.
Yang et al.
Bioorg.Med.Chem.Lett., 2012;22:4907
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