Inhibitor of Hedgehog (Hh) signaling (IC50
M in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α
. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold with the permission of AstraZeneca UK Ltd.
Discovery of novel hedgehog antagonists from cell-based screening: isoteric modification of p38 bisamides as potent inhibitors of SMO.
Yang et al.