AZ 12080282 dihydrochloride

Discontinued Product

4838 has been discontinued.
View all Hedgehog Signaling Inhibitors products.
AZ 12080282 dihydrochloride | Hedgehog Signaling Inhibitors
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Description: Inhibitor of Hedgehog (Hh) signaling

Chemical Name: N-[5-(1H-Imidazol-2-yl)-2-methylphenyl]-4-(2-pyridinylmethoxy)benzamide dihydrochloride

Purity: ≥98%

Product Details

Biological Activity

AZ 12080282 dihydrochloride is an inhibitor of Hedgehog (Hh) signaling (IC50 <0.012 μM in a firefly reporter assay against the Hh pathway). Shown to displace cyclopamine in HeLa cells expressing Smoothened. Exhibits selectivity against p38α. Orally bioavailable.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.

Product Datasheets

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