Begacestat

Catalog # Availability Size / Price Qty
4283/10
4283/50
Secretase Inhibitors Small Molecule
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Description: γ-secretase inhibitor; lowers Aβ40 and Aβ42 levels
Alternative Names: GSI-953

Chemical Name: 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

γ-secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of Aβ42 and Aβ40 (EC50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active.

Technical Data

M.Wt:
391.74
Formula:
C9H8ClF6NO3S2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
769169-27-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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