BIM 189
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Description: Bombesin antagonist
Alternative Names: [D-Phe6,Leu13,Cpa14]bombesin-(6-14)NH2
Biological Activity
BIM 189 is a bombesin antagonist that reduces bombesin-induced satiety.Technical Data
M.Wt:
1137.73
Formula:
C56H73ClN14O10
Sequence:
FQWAVGHLF
(Modifications: Phe-1 = D-Phe, Phe-9 = 4-Cl-Phe & C-terminal amide)
Solubility:
Soluble to 2 mg/ml in 20% acetonitrile
Storage:
Store at -20°C
CAS No:
142062-55-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Effects of bombesin, of a new bombesin agonist (BIM187) and a new antagonist (BIM189) on food intake in rats, in relation to cholecystokinin.
Laferrere et al.
Eur.J.Pharmacol., 1992;215:23 -
Short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig acinar cells.
Coy et al.
Eur.J.Pharmacol., 1990;190:31
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